M
Maria Timofeeva
Researcher at University of Southern Denmark
Publications - 105
Citations - 4645
Maria Timofeeva is an academic researcher from University of Southern Denmark. The author has contributed to research in topics: Genome-wide association study & Odds ratio. The author has an hindex of 32, co-authored 90 publications receiving 3394 citations. Previous affiliations of Maria Timofeeva include Western General Hospital & University of London.
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Journal ArticleDOI
Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes
James D. McKay,Rayjean J. Hung,Younghun Han,Xuchen Zong,Robert Carreras-Torres,David C. Christiani,Neil E. Caporaso,Mattias Johansson,Xiangjun Xiao,Yafang Li,Jinyoung Byun,Alison M. Dunning,Karen A. Pooley,David C. Qian,Xuemei Ji,Geoffrey Liu,Maria Timofeeva,Stig E. Bojesen,Stig E. Bojesen,Stig E. Bojesen,Xifeng Wu,Loic Le Marchand,Demetrios Albanes,Heike Bickeböller,Melinda C. Aldrich,William S. Bush,Adonina Tardón,Gad Rennert,M. Dawn Teare,John K. Field,Lambertus A. Kiemeney,Philip Lazarus,Aage Haugen,Stephen Lam,Matthew B. Schabath,Angeline S. Andrew,Hongbing Shen,Yun Chul Hong,Jian-Min Yuan,Pier Alberto Bertazzi,Angela Cecilia Pesatori,Yuanqing Ye,Nancy Diao,Li Su,Ruyang Zhang,Yonathan Brhane,Natasha B. Leighl,Jakob S Johansen,Anders Mellemgaard,Walid Saliba,Christopher A. Haiman,Lynne R. Wilkens,Ana Fernández-Somoano,Guillermo Fernández-Tardón,Henricus F. M. van der Heijden,Jin Hee Kim,Juncheng Dai,Zhibin Hu,Michael P.A. Davies,Michael W. Marcus,Hans Brunnström,Jonas Manjer,Olle Melander,David C. Muller,Kim Overvad,Antonia Trichopoulou,Rosario Tumino,Jennifer A. Doherty,Matt P Barnett,Chu Chen,Gary E. Goodman,Angela Cox,Fiona Taylor,Penella J. Woll,Irene Brüske,H-Erich Wichmann,H-Erich Wichmann,Judith Manz,Thomas Muley,Angela Risch,Albert Rosenberger,Kjell Grankvist,Mikael Johansson,Frances A. Shepherd,Ming-Sound Tsao,Susanne M. Arnold,Eric B. Haura,Ciprian Bolca,Ivana Holcatova,Vladimir Janout,Milica Kontic,Jolanta Lissowska,Anush Mukeria,Simona Ognjanovic,Tadeusz M Orlowski,Ghislaine Scelo,Beata Swiatkowska,David Zaridze,Per Bakke,Vidar Skaug,Shanbeh Zienolddiny,Eric J. Duell,Lesley M. Butler,Woon-Puay Koh,Yu-Tang Gao,Richard S. Houlston,John McLaughlin,Victoria L. Stevens,Philippe Joubert,Maxime Lamontagne,David C. Nickle,Ma'en Obeidat,Wim Timens,Bin Zhu,Lei Song,Linda Kachuri,María Soler Artigas,María Soler Artigas,Martin D. Tobin,Martin D. Tobin,Louise V. Wain,Louise V. Wain,Thorunn Rafnar,Thorgeir E. Thorgeirsson,Gunnar W Reginsson,Kari Stefansson,Dana B. Hancock,Laura J. Bierut,Margaret R. Spitz,Nathan C. Gaddis,Sharon M. Lutz,Fangyi Gu,Eric O. Johnson,Ahsan Kamal,Claudio W. Pikielny,Dakai Zhu,Sara Lindstroem,Xia Jiang,Rachel F. Tyndale,Rachel F. Tyndale,Georgia Chenevix-Trench,Jonathan Beesley,Yohan Bossé,Stephen J. Chanock,Paul Brennan,Maria Teresa Landi,Christopher I. Amos +146 more
TL;DR: 18 susceptibility loci achieving genome-wide significance are identified, including 10 new loci linked with lung cancer overall and six loci associated with lung adenocarcinoma, highlighting the striking heterogeneity in genetic susceptibility across the histological subtypes of lung cancer.
Journal ArticleDOI
Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer
Yufei Wang,James McKay,Thorunn Rafnar,Zhaoming Wang,Maria Timofeeva,Peter Broderick,Xuchen Zong,Marina Laplana,Yongyue Wei,Younghun Han,Amy Lloyd,Manon Delahaye-Sourdeix,Daniel Chubb,Valerie Gaborieau,William Wheeler,Nilanjan Chatterjee,Gudmar Thorleifsson,Patrick Sulem,Geoffrey Liu,Rudolf Kaaks,Marc Henrion,Ben Kinnersley,Maxime Vallée,Florence LeCalvez-Kelm,Victoria L. Stevens,Susan M. Gapstur,Wei V. Chen,David Zaridze,Neonilia Szeszenia-Dabrowska,Jolanta Lissowska,Peter Rudnai,Eleonora Fabianova,Dana Mates,Vladimir Bencko,Lenka Foretova,Vladimir Janout,Hans E. Krokan,Maiken Elvestad Gabrielsen,Frank Skorpen,Lars J. Vatten,Inger Njølstad,Chu Chen,Gary E. Goodman,Simone Benhamou,Tõnu Vooder,Kristjan Välk,Mari Nelis,Andres Metspalu,Marcin Lener,Jan Lubinski,Mattias Johansson,Paolo Vineis,Antonio Agudo,Françoise Clavel-Chapelon,H. Bas Bueno-de-Mesquita,H. Bas Bueno-de-Mesquita,Dimitrios Trichopoulos,Dimitrios Trichopoulos,Kay-Tee Khaw,Mikael Johansson,Elisabete Weiderpass,Anne Tjønneland,Elio Riboli,Mark Lathrop,Ghislaine Scelo,Demetrius Albanes,Neil E. Caporaso,Yuanqing Ye,Jian Gu,Xifeng Wu,Margaret R. Spitz,Hendrik Dienemann,Albert Rosenberger,Li Su,Athena Matakidou,T. Eisen,Kari Stefansson,Angela Risch,Stephen J. Chanock,David C. Christiani,Rayjean J. Hung,Paul Brennan,Maria Teresa Landi,Richard S. Houlston,Christopher I. Amos +84 more
TL;DR: The analysis demonstrates that imputation can identify rare disease-causing variants with substantive effects on cancer risk from preexisting genome-wide association study data and provides further evidence for inherited genetic susceptibility to lung cancer and its biological basis.
Journal ArticleDOI
Genome-wide Association Study in 79,366 European-ancestry Individuals Informs the Genetic Architecture of 25-Hydroxyvitamin D Levels
Xia Jiang,Xia Jiang,Paul F. O'Reilly,Hugues Aschard,Hugues Aschard,Yi-Hsiang Hsu,Yi-Hsiang Hsu,J. Brent Richards,Josée Dupuis,Josée Dupuis,Erik Ingelsson,Erik Ingelsson,David Karasik,Stefan Pilz,Diane J. Berry,Bryan Kestenbaum,Ju-Sheng Zheng,Jian'an Luan,Eleni Sofianopoulou,Elizabeth A. Streeten,Demetrius Albanes,Pamela L. Lutsey,Lu Yao,Weihong Tang,Michael J. Econs,Henri Wallaschofski,Henry Völzke,Ang Zhou,Chris Power,Mark I. McCarthy,Erin D. Michos,Eric Boerwinkle,Stephanie J. Weinstein,Neal D. Freedman,Wen-Yi Huang,Natasja M. van Schoor,Nathalie van der Velde,Nathalie van der Velde,Lisette C. P. G. M. de Groot,Anke W. Enneman,L. Adrienne Cupples,L. Adrienne Cupples,Sarah L. Booth,Ramachandran S. Vasan,Ching-Ti Liu,Yanhua Zhou,Samuli Ripatti,Claes Ohlsson,Liesbeth Vandenput,Mattias Lorentzon,Johan G. Eriksson,M. Kyla Shea,Denise K. Houston,Stephen B. Kritchevsky,Yongmei Liu,Kurt Lohman,Luigi Ferrucci,Munro Peacock,Christian Gieger,Marian Beekman,Eline Slagboom,Joris Deelen,Joris Deelen,Diana van Heemst,Marcus E. Kleber,Winfried März,Winfried März,Winfried März,Ian H. de Boer,Alexis C. Wood,Jerome I. Rotter,Stephen S. Rich,Cassianne Robinson-Cohen,Martin den Heijer,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Alana Cavadino,Alana Cavadino,Peter K. Joshi,James F. Wilson,Caroline Hayward,Lars Lind,Karl Michaëlsson,Stella Trompet,M. Carola Zillikens,André G. Uitterlinden,Fernando Rivadeneira,Linda Broer,Lina Zgaga,Harry Campbell,Evropi Theodoratou,Susan M. Farrington,Maria Timofeeva,Malcolm G. Dunlop,Ana M. Valdes,Ana M. Valdes,Emmi Tikkanen,Terho Lehtimäki,Leo-Pekka Lyytikäinen,Mika Kähönen,Olli T. Raitakari,Vera Mikkilä,M. Arfan Ikram,Naveed Sattar,J. Wouter Jukema,Nicholas J. Wareham,Claudia Langenberg,Nita G. Forouhi,Thomas E. Gundersen,Kay-Tee Khaw,Adam S. Butterworth,John Danesh,John Danesh,Tim D. Spector,Thomas J. Wang,Elina Hyppönen,Elina Hyppönen,Peter Kraft,Douglas P. Kiel,Douglas P. Kiel +119 more
TL;DR: In a genome-wide association study of 79,366 individuals, Jiang et al. replicate four and identify two new genetic loci for serum levels of 25-hydroxyvitamin D and find evidence for a shared genetic basis with autoimmune diseases.
Journal ArticleDOI
Serum uric acid levels and multiple health outcomes: umbrella review of evidence from observational studies, randomised controlled trials, and Mendelian randomisation studies
Xue Li,Xiangrui Meng,Maria Timofeeva,Ioanna Tzoulaki,Konstantinos K. Tsilidis,Konstantinos K. Tsilidis,John P. A. Ioannidis,Harry Campbell,Evropi Theodoratou +8 more
TL;DR: Despite a few hundred systematic reviews, meta-analyses, and Mendelian randomisation studies exploring 136 unique health outcomes, convincing evidence of a clear role of SUA level only exists for gout and nephrolithiasis.
Journal ArticleDOI
Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls
Maria Timofeeva,Rayjean J. Hung,Thorunn Rafnar,David C. Christiani,John K. Field,Heike Bickeböller,Angela Risch,James McKay,Yufei Wang,Juncheng Dai,Valerie Gaborieau,John R. McLaughlin,Darren R. Brenner,Steven A. Narod,Neil E. Caporaso,Demetrius Albanes,Michael J. Thun,T. Eisen,H.-Erich Wichmann,Albert Rosenberger,Younghun Han,Wei Chen,Dakai Zhu,Margaret R. Spitz,Xifeng Wu,Mala Pande,Yang Zhao,David Zaridze,Neonilia Szeszenia-Dabrowska,Jolanta Lissowska,Peter Rudnai,Eleonora Fabianova,Dana Mates,Vladimir Bencko,Lenka Foretova,Vladimir Janout,Hans E. Krokan,Maiken Elvestad Gabrielsen,Frank Skorpen,Lars J. Vatten,Inger Njølstad,Chu Chen,Gary E. Goodman,Mark Lathrop,Simone Benhamou,Tõnu Vooder,Kristjan Välk,Mari Nelis,Andres Metspalu,Olaide Y. Raji,Ying Chen,John R. Gosney,Triantafillos Liloglou,Thomas Muley,Hendrik Dienemann,Gudmar Thorleifsson,Hongbing Shen,Kari Stefansson,Paul Brennan,Christopher I. Amos,Richard S. Houlston,Maria Teresa Landi +61 more
TL;DR: A large analysis of 16 genome-wide association studies provides additional evidence for the role of inherited genetic susceptibility to lung cancer and insight into biological differences in the development of the different histological types of lung cancer.