H
Helen N. Lyon
Researcher at Harvard University
Publications - 29
Citations - 9286
Helen N. Lyon is an academic researcher from Harvard University. The author has contributed to research in topics: Genome-wide association study & Single-nucleotide polymorphism. The author has an hindex of 21, co-authored 29 publications receiving 8948 citations. Previous affiliations of Helen N. Lyon include Boston Children's Hospital & Broad Institute.
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Journal ArticleDOI
Genome-Wide Association Analysis Identifies Loci for Type 2 Diabetes and Triglyceride Levels
Richa Saxena,Benjamin F. Voight,Valeriya Lyssenko,Noël P. Burtt,Paul I.W. de Bakker,Hong Chen,Jeffrey J. Roix,Sekar Kathiresan,Joel N. Hirschhorn,Mark J. Daly,Thomas E. Hughes,Leif Groop,David Altshuler,Peter Almgren,Jose C. Florez,Joanne M. Meyer,Kristin Ardlie,Kristina Bengtsson Boström,Bo Isomaa,Guillaume Lettre,Ulf Lindblad,Helen N. Lyon,Olle Melander,Christopher Newton-Cheh,Peter Nilsson,Marju Orho-Melander,Lennart Råstam,Elizabeth K. Speliotes,Marja-Riitta Taskinen,Tiinamaija Tuomi,Candace Guiducci,Anna Berglund,Joyce Carlson,Lauren Gianniny,Rachel Hackett,Liselotte Hall,Johan Holmkvist,Esa Laurila,Marketa Sjögren,Maria Sterner,Aarti Surti,Margareta Svensson,Malin Svensson,Ryan Tewhey,Brendan Blumenstiel,Melissa Parkin,Matthew DeFelice,Rachel Barry,Wendy Brodeur,Jody Camarata,Nancy Chia,Mary Fava,John G. Gibbons,Bob Handsaker,Claire M. Healy,Kieu Nguyen,Casey Gates,Carrie Sougnez,Diane Gage,Marcia M. Nizzari,Stacey Gabriel,Gung-Wei Chirn,Qicheng Ma,Hemang Parikh,Delwood Richardson,Darrell O. Ricke,Shaun Purcell +66 more
TL;DR: The discovery of associated variants in unsuspected genes and outside coding regions illustrates the ability of genome-wide association studies to provide potentially important clues to the pathogenesis of common diseases.
Journal ArticleDOI
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
Cristen J. Willer,Elizabeth K. Speliotes,Elizabeth K. Speliotes,Ruth J. F. Loos,Shengxu Li,Cecilia M. Lindgren,Iris M. Heid,Sonja I. Berndt,Amanda F. Elliott,Amanda F. Elliott,Anne U. Jackson,Claudia Lamina,Guillaume Lettre,Guillaume Lettre,Noha Lim,Helen N. Lyon,Helen N. Lyon,Steven A. McCarroll,Steven A. McCarroll,Konstantinos A. Papadakis,Lu Qi,Joshua C. Randall,Rosa Maria Roccasecca,Serena Sanna,Paul Scheet,Michael N. Weedon,Eleanor Wheeler,Jing Hua Zhao,Leonie C. Jacobs,Inga Prokopenko,Nicole Soranzo,Nicole Soranzo,Toshiko Tanaka,Nicholas J. Timpson,Peter Almgren,Amanda J. Bennett,Richard N. Bergman,Sheila Bingham,Lori L. Bonnycastle,Morris Brown,Noël P. Burtt,Peter S. Chines,Lachlan J. M. Coin,Francis S. Collins,John M. C. Connell,Cyrus Cooper,George Davey Smith,Elaine M. Dennison,Parimal Deodhar,Paul Elliott,Michael R. Erdos,Karol Estrada,David M. Evans,Lauren Gianniny,Christian Gieger,Christopher J. Gillson,Candace Guiducci,Rachel Hackett,David Hadley,Alistair S. Hall,Aki S. Havulinna,Johannes Hebebrand,Albert Hofman,Bo Isomaa,Kevin B. Jacobs,Toby Johnson,Toby Johnson,Pekka Jousilahti,Zorica Jovanovic,Zorica Jovanovic,Kay-Tee Khaw,Peter Kraft,Mikko Kuokkanen,Mikko Kuokkanen,Johanna Kuusisto,Jaana Laitinen,Edward G. Lakatta,Jian'an Luan,Robert Luben,Massimo Mangino,Wendy L. McArdle,Thomas Meitinger,Antonella Mulas,Patricia B. Munroe,Narisu Narisu,Andy R Ness,Kate Northstone,Stephen O'Rahilly,Stephen O'Rahilly,Carolin Purmann,Carolin Purmann,Matthew G. Rees,Martin Ridderstråle,Susan M. Ring,Fernando Rivadeneira,Aimo Ruokonen,Manjinder S. Sandhu,Manjinder S. Sandhu,Jouko Saramies,Laura J. Scott,Angelo Scuteri,Kaisa Silander,Matthew A. Sims,Kijoung Song,Jonathan Stephens,Suzanne Stevens,Heather M. Stringham,Y. C. Loraine Tung,Y. C. Loraine Tung,Timo T. Valle,Cornelia M. van Duijn,Karani Santhanakrishnan Vimaleswaran,Karani Santhanakrishnan Vimaleswaran,Peter Vollenweider,Gérard Waeber,Chris Wallace,Richard M. Watanabe,Dawn M. Waterworth,Nicholas A. Watkins,Jacqueline C. M. Witteman,Eleftheria Zeggini,Guangju Zhai,M. Carola Zillikens,David Altshuler,David Altshuler,Mark J. Caulfield,Stephen J. Chanock,I. Sadaf Farooqi,I. Sadaf Farooqi,Luigi Ferrucci,Jack M. Guralnik,Andrew T. Hattersley,Frank B. Hu,Marjo-Riitta Järvelin,Markku Laakso,Vincent Mooser,Ken K. Ong,Willem H. Ouwehand,Willem H. Ouwehand,Veikko Salomaa,Nilesh J. Samani,Tim D. Spector,Tiinamaija Tuomi,Jaakko Tuomilehto,Manuela Uda,André G. Uitterlinden,Nicholas J. Wareham,Panagiotis Deloukas,Timothy M. Frayling,Leif Groop,Leif Groop,Richard B. Hayes,David J. Hunter,David J. Hunter,Karen L. Mohlke,Leena Peltonen,Leena Peltonen,Leena Peltonen,David Schlessinger,David P. Strachan,H-Erich Wichmann,Mark I. McCarthy,Michael Boehnke,Inês Barroso,Gonçalo R. Abecasis,Joel N. Hirschhorn,Joel N. Hirschhorn +166 more
TL;DR: Several of the likely causal genes are highly expressed or known to act in the central nervous system (CNS), emphasizing, as in rare monogenic forms of obesity, the role of the CNS in predisposition to obesity.
Journal ArticleDOI
A common genetic variant is associated with adult and childhood obesity.
Alan Herbert,Norman P. Gerry,Matthew B. McQueen,I. M. Heid,Arne Pfeufer,Thomas Illig,H.-Erich Wichmann,H.-Erich Wichmann,Thomas Meitinger,David J. Hunter,David J. Hunter,Frank B. Hu,Frank B. Hu,Graham A. Colditz,Anke Hinney,Johannes Hebebrand,Kerstin Koberwitz,Kerstin Koberwitz,Xiaofeng Zhu,Richard S. Cooper,Kristin G. Ardlie,Helen N. Lyon,Helen N. Lyon,Helen N. Lyon,Joel N. Hirschhorn,Joel N. Hirschhorn,Joel N. Hirschhorn,Nan M. Laird,Marc E. Lenburg,Christoph Lange,Christoph Lange,Michael F. Christman +31 more
TL;DR: A dense whole-genome scan of DNA samples from the Framingham Heart Study participants was used to identify a common genetic variant near the INSIG2 gene associated with obesity, suggesting that common genetic polymorphisms are important determinants of obesity.
Journal ArticleDOI
Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution
Cecilia M. Lindgren,Iris M. Heid,Joshua C. Randall,Claudia Lamina,Valgerdur Steinthorsdottir,Lu Qi,Elizabeth K. Speliotes,Elizabeth K. Speliotes,Gudmar Thorleifsson,Cristen J. Willer,Blanca M. Herrera,Anne U. Jackson,Noha Lim,Paul Scheet,Nicole Soranzo,Nicole Soranzo,Najaf Amin,Yurii S. Aulchenko,John C. Chambers,Alexander W. Drong,Jia N.an Luan,Helen N. Lyon,Helen N. Lyon,Fernando Rivadeneira,Serena Sanna,Nicholas J. Timpson,M. Carola Zillikens,Hua Zhao Jing,Peter Almgren,Stefania Bandinelli,Amanda J. Bennett,Richard N. Bergman,Lori L. Bonnycastle,Suzannah Bumpstead,Stephen J. Chanock,Lynn Cherkas,Peter S. Chines,Lachlan J. M. Coin,Cyrus Cooper,Gabriel Crawford,Angela Doering,Anna F. Dominiczak,Alex S. F. Doney,Shah Ebrahim,Paul Elliott,Michael R. Erdos,Karol Estrada,Luigi Ferrucci,Guido Fischer,Nita G. Forouhi,Christian Gieger,Harald Grallert,Christopher J. Groves,Scott M. Grundy,Candace Guiducci,David Hadley,Anders Hamsten,Aki S. Havulinna,Albert Hofman,Rolf Holle,John W. Holloway,Thomas Illig,Bo Isomaa,Leonie C. Jacobs,Karen A. Jameson,Pekka Jousilahti,Fredrik Karpe,Johanna Kuusisto,Jaana Laitinen,G. Mark Lathrop,Debbie A Lawlor,Massimo Mangino,Wendy L. McArdle,Thomas Meitinger,Mario A. Morken,Andrew P. Morris,Patricia B. Munroe,Narisu Narisu,Anna Nordström,Peter Nordström,Ben A. Oostra,Colin N. A. Palmer,Felicity Payne,John F. Peden,Inga Prokopenko,Frida Renström,Aimo Ruokonen,Veikko Salomaa,Manjinder S. Sandhu,Manjinder S. Sandhu,Laura J. Scott,Angelo Scuteri,Kaisa Silander,Kijoung Song,Xin Yuan,Heather M. Stringham,Amy J. Swift,Tiinamaija Tuomi,Manuela Uda,Peter Vollenweider,Gérard Waeber,Chris Wallace,G. Bragi Walters,Michael N. Weedon,Jacqueline C.M. Witteman,Cuilin Zhang,Weihua Zhang,Mark J. Caulfield,Francis S. Collins,George Davey Smith,Ian N. M. Day,Paul W. Franks,Andrew T. Hattersley,Frank B. Hu,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Augustine Kong,Jaspal S. Kooner,Markku Laakso,Edward G. Lakatta,Vincent Mooser,Andrew D. Morris,Leena Peltonen,Leena Peltonen,Nilesh J. Samani,Tim D. Spector,David P. Strachan,Toshiko Tanaka,Toshiko Tanaka,Jaakko Tuomilehto,André G. Uitterlinden,Cornelia M. van Duijn,Nicholas J. Wareham,Hugh Watkins,Dawn M. Waterworth,Michael Boehnke,Panos Deloukas,Leif Groop,Leif Groop,David J. Hunter,David J. Hunter,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,David Schlessinger,H.-Erich Wichmann,Timothy M. Frayling,Gonçalo R. Abecasis,Joel N. Hirschhorn,Joel N. Hirschhorn,Ruth J. F. Loos,Kari Stefansson,Kari Stefansson,Karen L. Mohlke,Inês Barroso,Mark I. McCarthy +155 more
TL;DR: By focusing on anthropometric measures of central obesity and fat distribution, a meta-analysis of 16 genome-wide association studies informative for adult waist circumference and waist–hip ratio identified three loci implicated in the regulation of human adiposity.
Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution
Cecilia M. Lindgren,Iris M. Heid,Joshua C. Randall,Claudia Lamina,Valgerdur Steinthorsdottir,Lu Qi,Elizabeth K. Speliotes,Gudmar Thorleifsson,Cristen J. Willer,Blanca M. Herrera,Anne U. Jackson,Noha Lim,Paul Scheet,Nicole Soranzo,Najaf Amin,Yurii S. Aulchenko,John C. Chambers,Alexander W. Drong,Jian'an Luan,Helen N. Lyon,Fernando Rivadeneira,Serena Sanna,Nicholas J. Timpson,M. Carola Zillikens,Jing Hua Zhao,Peter Almgren,Stefania Bandinelli,Amanda J. Bennett,Richard N. Bergman,Lori L. Bonnycastle,Suzannah Bumpstead,Stephen J. Chanock,Lynn Cherkas,Peter S. Chines,Lachlan J. M. Coin,Cyrus Cooper,Gabriel Crawford,Angela Doering,Anna F. Dominiczak,Alex S. F. Doney,Shah Ebrahim,Paul Elliott,Michael R. Erdos,Karol Estrada,Luigi Ferrucci,Guido Fischer,Nita G. Forouhi,Christian Gieger,Harald Grallert,Christopher J. Groves,Scott M. Grundy,Candace Guiducci,David Hadley,Anders Hamsten,Aki S. Havulinna,Albert Hofman,Rolf Holle,John W. Holloway,Thomas Illig,Bo Isomaa,Leonie C. Jacobs,Karen A. Jameson,Pekka Jousilahti,Fredrik Karpe,Johanna Kuusisto,Jaana Laitinen,G. Mark Lathrop,Debbie A Lawlor,Massimo Mangino,Wendy L. McArdle,Thomas Meitinger,Mario A. Morken,Andrew P. Morris,Patricia B. Munroe,Narisu Narisu,Anna Nordström,Peter Nordström,Ben A. Oostra,Colin N. A. Palmer,Felicity Payne,John F. Peden,Inga Prokopenko,Frida Renström,Aimo Ruokonen,Veikko Salomaa,Manjinder S. Sandhu,Laura J. Scott,Angelo Scuteri,Kaisa Silander,Kijoung Song,Xin Yuan,Heather M. Stringham,Amy J. Swift,Tiinamaija Tuomi,Manuela Uda,Peter Vollenweider,Gérard Waeber,Chris Wallace,G. Bragi Walters,Michael N. Weedon,Jacqueline C.M. Witteman,Cuilin Zhang,Weihua Zhang,Mark J. Caulfield,Francis S. Collins,George Davey Smith,Ian N.M. Day,Paul W. Franks,Andrew T. Hattersley,Frank B. Hu,Marjo-Riitta Järvelin,Augustine Kong,Jaspal S. Kooner,Markku Laakso,Edward G. Lakatta,Vincent Mooser,Andrew D. Morris,Leena Peltonen,Nilesh J. Samani,Tim D. Spector,David P. Strachan,Toshiko Tanaka,Jaakko Tuomilehto,André G. Uitterlinden,Cornelia M. van Duijn,Nicholas J. Wareham,Dawn M. Waterworth,Michael Boehnke,Panos Deloukas,Leif Groop,David J. Hunter,Unnur Thorsteinsdottir,David Schlessinger,H.-Erich Wichmann,Timothy M. Frayling,Gonçalo R. Abecasis,Joel N. Hirschhorn,Ruth J. F. Loos,Kari Stefansson,Karen L. Mohlke,Inês Barroso +140 more
TL;DR: Vandervell Foundation and Wellcome Trust (068545/Z/02, GR072960 as discussed by the authors, GR076113, GR069224, GR086596/Z /08/Z)