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Xiaojiang Xu
Researcher at National Institutes of Health
Publications - 58
Citations - 2286
Xiaojiang Xu is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Glucocorticoid receptor & Medicine. The author has an hindex of 22, co-authored 48 publications receiving 1561 citations. Previous affiliations of Xiaojiang Xu include University of Virginia & Research Triangle Park.
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Journal ArticleDOI
scRNA-seq Profiling of Human Testes Reveals the Presence of the ACE2 Receptor, A Target for SARS-CoV-2 Infection in Spermatogonia, Leydig and Sertoli Cells.
Zhengpin Wang,Xiaojiang Xu +1 more
TL;DR: Investigation of the expression pattern of ACE2 in adult human testes at the level of single-cell transcriptomes indicates that the human testis is a potential target of SARS-CoV-2 infection, which may have significant impact on understanding of the pathophysiology of this rapidly spreading disease.
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Bacteria Boost Mammalian Host NAD Metabolism by Engaging the Deamidated Biosynthesis Pathway.
Igor Shats,Jason Williams,Juan Liu,Mikhail V. Makarov,Xiaoyue Wu,Fred B. Lih,Leesa J. Deterding,Chaemin Lim,Xiaojiang Xu,Thomas A. Randall,Ethan Lee,Wenling Li,Wei Fan,Jian-Liang Li,Marina Sokolsky,Alexander V. Kabanov,Leping Li,Marie E. Migaud,Jason W. Locasale,Xiaoling Li +19 more
TL;DR: An unexpected trans-kingdom cooperation between bacteria and mammalian cells wherein bacteria contribute to host NAD biosynthesis, revealing an important role of bacteria-enabled deamidated pathway in host NAD metabolism.
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Intestinal Epithelial Sirtuin 1 Regulates Intestinal Inflammation During Aging in Mice by Altering the Intestinal Microbiota
Alicia S. Wellman,Mallikarjuna R. Metukuri,Nevzat Kazgan,Xiaojiang Xu,Qing Xu,Natalie S.X. Ren,Agnieszka Czopik,Michael J. Shanahan,Ashley Kang,Willa Chen,M. Andrea Azcarate-Peril,Ajay S. Gulati,David C. Fargo,Leonard Guarente,Xiaoling Li +14 more
TL;DR: In analyses of intestinal tissues, colitis induction, and gut microbiota in mice with intestinal epithelial disruption of SIRT1, this protein is found to prevent intestinal inflammation by regulating the gut microbiota.
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Reproductive toxicity of low level bisphenol A exposures in a two-generation zebrafish assay: Evidence of male-specific effects
Jiangfei Chen,Yanyan Xiao,Zengxin Gai,Rong Li,Zixu Zhu,Chenglian Bai,Robert L. Tanguay,Xiaojiang Xu,Changjiang Huang,Qiaoxiang Dong +9 more
TL;DR: Low level BPA exposures for continuous two generations not only affects sex ratio and sperm quantity/quality in F1 and F2 adults, reproductive success in offspring from F2 parents, but also perturbs various molecular pathways potentially contributing to these BPA induced male-specific reproductive defects.
Journal ArticleDOI
Tolerogenic properties of lymphatic endothelial cells are controlled by the lymph node microenvironment.
Jarish N. Cohen,Eric F. Tewalt,Sherin J. Rouhani,Erica L. Buonomo,Amber N. Bruce,Xiaojiang Xu,Stefan Bekiranov,Yang Xin Fu,Victor H. Engelhard +8 more
TL;DR: This article showed that lymphatic endothelial cells in the lymph node medullary sinus express the highest levels of peripheral tissue antigens and PD-L1, and are the only subpopulation that expresses tyrosinase epitope.