M
Monowarul Mobin Siddique
Researcher at Universiti Brunei Darussalam
Publications - 20
Citations - 1494
Monowarul Mobin Siddique is an academic researcher from Universiti Brunei Darussalam. The author has contributed to research in topics: Sphingolipid & Insulin resistance. The author has an hindex of 12, co-authored 18 publications receiving 1133 citations. Previous affiliations of Monowarul Mobin Siddique include SingHealth & National University of Singapore.
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Journal ArticleDOI
Caffeine stimulates hepatic lipid metabolism by the autophagy‐lysosomal pathway in mice
Rohit A. Sinha,Benjamin L. Farah,Brijesh K. Singh,Monowarul Mobin Siddique,Ying Li,Yajun Wu,Olga Ilkayeva,Jessica R. Gooding,Jianhong Ching,Jin Zhou,Laura Martínez,Sherwin Xie,Boon-Huat Bay,Scott A. Summers,Christopher B. Newgard,Paul M. Yen +15 more
TL;DR: It is demonstrated that caffeine reduces intrahepatic lipid content and stimulates β‐oxidation in hepatic cells and liver by an autophagy‐lysosomal pathway and is a potent stimulator of hepatic autophagic flux.
Journal ArticleDOI
Targeting a ceramide double bond improves insulin resistance and hepatic steatosis.
Bhagirath Chaurasia,Trevor S. Tippetts,Rafael Mayoral Monibas,Jinqi Liu,Ying Li,Liping Wang,Joseph L. Wilkerson,C. Rufus Sweeney,Renato Felipe Pereira,Doris Hissako Sumida,J. Alan Maschek,James E. Cox,Vincent A. Kaddai,Graeme I. Lancaster,Monowarul Mobin Siddique,Annelise M Poss,Mackenzie J. Pearson,Santhosh Satapati,Heather Zhou,David G. McLaren,Stephen F. Previs,Ying Chen,Ying Qian,Aleksandr Petrov,Margaret Wu,Xiaolan Shen,Jun Yao,Christian N. Nunes,Andrew D. Howard,Liangsu Wang,Mark D. Erion,Jared Rutter,Jared Rutter,William L. Holland,David E. Kelley,Scott A. Summers +35 more
TL;DR: Mechanistic studies revealed ceramide actions that promoted lipid uptake and storage and impaired glucose utilization, none of which could be recapitulated by (dihydro)ceramides that lacked the critical double bond, suggest that inhibition of DES1 may provide a means of treating hepatic steatosis and metabolic disorders.
Journal ArticleDOI
Adipocyte Ceramides Regulate Subcutaneous Adipose Browning, Inflammation, and Metabolism.
Bhagirath Chaurasia,Vincent A. Kaddai,Graeme I. Lancaster,Darren C. Henstridge,Sandhya Sriram,Dwight L. A. Galam,Venkatesh Gopalan,K. N. Bhanu Prakash,S. Sendhil Velan,Sarada Bulchand,Teh Jing Tsong,Mei Wang,Monowarul Mobin Siddique,Guan Yuguang,Kristmundur Sigmundsson,Natalie A. Mellet,Jacquelyn M. Weir,Peter J. Meikle,M. Shabeer Yassin,Asim Shabbir,James A. Shayman,Yoshio Hirabayashi,Sue Anne Toh Ee Shiow,Shigeki Sugii,Scott A. Summers +24 more
TL;DR: It is demonstrated that subcutaneous adipose tissue of type 2 diabetics contains considerably more sphingolipids than non-diabetic, BMI-matched counterparts and that newly synthesized adipocyte sphingoipids are nutrient signals that drive changes in the adipose phenotype to influence whole-body energy expenditure and nutrient metabolism.
Journal ArticleDOI
Trp53-dependent DNA-repair is affected by the codon 72 polymorphism
TL;DR: The data highlight the functional differences between the Trp53 polymorphic variants, and suggest that their expression status may influence cancer risk.
Journal ArticleDOI
Ceramides and Glucosylceramides are independent antagonists of insulin signaling
Jose Antonio Chavez,Monowarul Mobin Siddique,Siew Tein Wang,Jianhong Ching,James A. Shayman,Scott A. Summers,Scott A. Summers +6 more
TL;DR: The role of ceramides and glucosylceramides in muscle and adipose tissue is investigated and it is concluded that they are independent and separable antagonists of insulin signaling.