C
Cathrin Dierkes
Researcher at Max Planck Society
Publications - 8
Citations - 487
Cathrin Dierkes is an academic researcher from Max Planck Society. The author has contributed to research in topics: Lymphatic system & Lymphangiogenesis. The author has an hindex of 6, co-authored 7 publications receiving 331 citations.
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Journal ArticleDOI
The role of fatty acid β-oxidation in lymphangiogenesis
Brian W. Wong,Xingwu Wang,Annalisa Zecchin,Bernard Thienpont,Ivo Cornelissen,Joanna Kalucka,Melissa García-Caballero,Rindert Missiaen,Hongling Huang,Ulrike Bruning,Silvia Blacher,Stefan Vinckier,Jermaine Goveia,Marlen Knobloch,Hui Zhao,Cathrin Dierkes,Chenyan Shi,René Hägerling,Veronica Moral-Darde,Sabine Wyns,Martin Lippens,Sebastian Jessberger,Sarah-Maria Fendt,Aernout Luttun,Agnès Noël,Friedemann Kiefer,Bart Ghesquière,Lieve Moons,Luc Schoonjans,Mieke Dewerchin,Guy Eelen,Diether Lambrechts,Peter Carmeliet +32 more
TL;DR: In transgenic mouse models, LEC-specific loss of CPT1A, a rate-controlling enzyme in fatty acid β-oxidation, impairs lymphatic development and replenishing acetyl coenzyme A by supplementing acetate rescues this process in vivo.
Journal ArticleDOI
Matrix stiffness controls lymphatic vessel formation through regulation of a GATA2-dependent transcriptional program
Maike Frye,Andrea Taddei,Cathrin Dierkes,Ines Martinez-Corral,Matthew Fielden,Henrik Ortsäter,Jan Kazenwadel,Dinis Pedro Calado,Pia Ostergaard,Marjo Salminen,Liqun He,Natasha L. Harvey,Friedemann Kiefer,Friedemann Kiefer,Taija Makinen +14 more
TL;DR: It is shown that lymphatic endothelial cell progenitors experience varying degrees of matrix stiffness during development, and that matrix stiffness regulates GATA2 expression to drive lymphatic vessel formation.
Journal ArticleDOI
An Evolutionarily Conserved Role for Polydom/Svep1 During Lymphatic Vessel Formation.
Terhi Karpanen,Yvonne Padberg,Serge A. van de Pavert,Cathrin Dierkes,Nanami Morooka,Josi Peterson-Maduro,Glenn van de Hoek,Max Adrian,Naoki Mochizuki,Kiyotoshi Sekiguchi,Friedemann Kiefer,Dörte Schulte,Stefan Schulte-Merker +12 more
TL;DR: In this article, the secreted Polydom/Svep1 protein was identified as essential for the formation of the lymphatic vasculature in mice and zebrafish.
Journal ArticleDOI
Distinct roles of VE‐cadherin for development and maintenance of specific lymph vessel beds
René Hägerling,Esther Hoppe,Esther Hoppe,Cathrin Dierkes,Martin Stehling,Taija Makinen,Stefan Butz,Dietmar Vestweber,Friedemann Kiefer,Friedemann Kiefer +9 more
TL;DR: It is demonstrated here the importance of VE‐cadherin for lymphatic vessel development and maintenance, which is however remarkably vessel bed‐specific.
Journal ArticleDOI
VIPAR, a quantitative approach to 3D histopathology applied to lymphatic malformations
René Hägerling,Dominik Drees,Aaron Scherzinger,Aaron Scherzinger,Cathrin Dierkes,Silvia Martin-Almedina,Stefan Butz,Kristiana Gordon,Michael Schäfers,Klaus Hinrichs,Pia Ostergaard,Dietmar Vestweber,Tobias Goerge,Sahar Mansour,Xiaoyi Jiang,Peter S. Mortimer,Friedemann Kiefer,Friedemann Kiefer +17 more
TL;DR: VIPAR is a volume-based tissue reconstruction data extraction and analysis approach that successfully distinguished healthy from lymphedematous and lymphangiomatous skin and its application is not limited to the vascular systems or skin.