Dengue NS2A Protein Orchestrates Virus Assembly.
Xuping Xie,Jing Zou,Xianwen Zhang,Xianwen Zhang,Yiyang Zhou,Andrew Routh,CongBao Kang,Vsevolod L. Popov,Xinwen Chen,Xinwen Chen,Qing Yin Wang,Hongping Dong,Pei Yong Shi +12 more
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TLDR
It is shown that dengue nonstructural protein 2A (NS2A protein) recruits viral RNA, structural proteins, and protease to the site of virion assembly and coordinates nucleocapsid and virus formation.About:
This article is published in Cell Host & Microbe.The article was published on 2019-11-13 and is currently open access. It has received 63 citations till now. The article focuses on the topics: Virion assembly & NS3.read more
Citations
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The role of the nonstructural protein NS2A in flavivirus assembly
TL;DR: The results further confirm the role of NS2A in virus assembly, demonstrate the importance of hydrophobic residues at codon 59 in this process, implicate the involvement of NS1A in the biogenesis of virus-induced membranes, and suggest a vital role for the virus- induced membranes in virusAssembly.
Journal ArticleDOI
Zika Virus NS2A-Mediated Virion Assembly
Xianwen Zhang,Xianwen Zhang,Xuping Xie,Hongjie Xia,Jing Zou,Linfen Huang,Vsevolod L. Popov,Xinwen Chen,Xinwen Chen,Pei Yong Shi +9 more
TL;DR: ZIKV NS2A plays a central role in recruiting viral RNA, structural protein prM/E, and viral NS2B/NS3 protease to the virion assembly site and orchestrates virus morphogenesis, demonstrating the specific role of these interactions in virus Morphogenesis.
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A Zika virus envelope mutation preceding the 2015 epidemic enhances virulence and fitness for transmission.
Chao Shan,Hongjie Xia,Sherry L. Haller,Sasha R. Azar,Yang Liu,Jianying Liu,Antonio E. Muruato,Rubing Chen,Shannan L. Rossi,Maki Wakamiya,Nikos Vasilakis,Rongjuan Pei,Camila R. Fontes-Garfias,Sanjay K. Singh,Xuping Xie,Scott C. Weaver,Pei Yong Shi +16 more
TL;DR: Overall, this study revealed E-V473M as a critical determinant for enhanced ZIKV virulence, intrauterine transmission during pregnancy, and viremia to facilitate urban transmission.
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Molecular Determinants of Flavivirus Virion Assembly
TL;DR: A review of recent advances in understanding of flavivirus virion assembly, including the intermolecular interactions between the viral structural (capsid) and nonstructural proteins (NS2A and NS2B-NS3), host factors, as well as features of the viral genomic RNA required for efficient virion RNA assembly, can be found in this article.
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Understanding Flavivirus Capsid Protein Functions: The Tip of the Iceberg.
Stephanea Sotcheff,Andrew Routh +1 more
TL;DR: Flaviviruses are enveloped positive-sense single-stranded RNA arboviruses, infectious to humans and many other animals and are transmitted primarily via tick or mosquito vectors, and capsid structure, nucleic acid interactions and how these give rise to multiple functions are reviewed.
References
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The Sequence Alignment/Map format and SAMtools
Heng Li,Bob Handsaker,Alec Wysoker,T. J. Fennell,Jue Ruan,Nils Homer,Gabor T. Marth,Gonçalo R. Abecasis,Richard Durbin +8 more
TL;DR: SAMtools as discussed by the authors implements various utilities for post-processing alignments in the SAM format, such as indexing, variant caller and alignment viewer, and thus provides universal tools for processing read alignments.
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Fast gapped-read alignment with Bowtie 2
TL;DR: Bowtie 2 combines the strengths of the full-text minute index with the flexibility and speed of hardware-accelerated dynamic programming algorithms to achieve a combination of high speed, sensitivity and accuracy.
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Cutadapt removes adapter sequences from high-throughput sequencing reads
TL;DR: The command-line tool cutadapt is developed, which supports 454, Illumina and SOLiD (color space) data, offers two adapter trimming algorithms, and has other useful features.
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The global distribution and burden of dengue
Samir Bhatt,Peter W. Gething,Oliver J. Brady,Jane P. Messina,Andrew Farlow,Catherine L. Moyes,John M. Drake,John M. Drake,John S. Brownstein,Anne G. Hoen,Osman Sankoh,Osman Sankoh,Monica F. Myers,Dylan B. George,Thomas Jaenisch,G. R. William Wint,Cameron P. Simmons,Thomas W. Scott,Thomas W. Scott,Jeremy Farrar,Jeremy Farrar,Simon I. Hay,Simon I. Hay +22 more
TL;DR: These new risk maps and infection estimates provide novel insights into the global, regional and national public health burden imposed by dengue and will help to guide improvements in disease control strategies using vaccine, drug and vector control methods, and in their economic evaluation.
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The global distribution and burden of dengue
Samir Bhatt,Peter W. Gething,Oliver J. Brady,Jane P. Messina,Andrew Farlow,Catherine L. Moyes,John M. Drake,John M. Drake,John S. Brownstein,Anne G. Hoen,Osman Sankoh,Osman Sankoh,Monica F. Myers,Dylan B. George,Thomas Jaenisch,G. R. William Wint,Cameron P. Simmons,Thomas W. Scott,Thomas W. Scott,Jeremy Farrar,Jeremy Farrar,Simon I. Hay,Simon I. Hay +22 more