Yanan Yue

TL;DR: It is shown that m6A is selectively recognized by the human YTH domain family 2 (YTHDF2) ‘reader’ protein to regulate mRNA degradation and established the role of YTH DF2 in RNA metabolism, showing that binding of Y THDF2 results in the localization of bound mRNA from the translatable pool to mRNA decay sites, such as processing bodies.

TL;DR: It is reported here that human METTL14 catalyzes m6A RNA methylation, and together with METTL3, the only previously known m 6A methyltransferase, these two proteins form a stable heterodimer core complex ofMETTL3-14 that functions in cellular m6 a deposition on mammalian nuclear RNAs.

TL;DR: The broad roles of m(6)A in regulating cell fates and embryonic development highlight the existence of another layer of epigenetic regulation at the RNA level, where mRNA is subjected to chemical modifications that affect protein expression.

TL;DR: A characterization of the full m6A methyltransferase complex in HeLa cells is reported identifying METTL3/METTL14/WTAP/VIRMA/HAKAI/ZC3H13 as the key components, and it is shown that VIRMA mediates preferential mRNA methylation in 3′UTR and near stop codon.

TL;DR: In this article, hyperbranched poly(2,5-silole)s [hb-P1(m), m = 1, 6] are synthesized for the first time in this work.