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Yanan Yue
Researcher at Zhejiang University
Publications - 11
Citations - 6607
Yanan Yue is an academic researcher from Zhejiang University. The author has contributed to research in topics: RNA & N6-Methyladenosine. The author has an hindex of 10, co-authored 11 publications receiving 4300 citations. Previous affiliations of Yanan Yue include The Chinese University of Hong Kong & Howard Hughes Medical Institute.
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Journal ArticleDOI
N6-methyladenosine-dependent regulation of messenger RNA stability
Xiao Wang,Zhike Lu,Adrian Gomez,Gary C. Hon,Yanan Yue,Dali Han,Ye Fu,Marc Parisien,Qing Dai,Guifang Jia,Bing Ren,Tao Pan,Chuan He +12 more
TL;DR: It is shown that m6A is selectively recognized by the human YTH domain family 2 (YTHDF2) ‘reader’ protein to regulate mRNA degradation and established the role of YTH DF2 in RNA metabolism, showing that binding of Y THDF2 results in the localization of bound mRNA from the translatable pool to mRNA decay sites, such as processing bodies.
Journal ArticleDOI
A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation
Jianzhao Liu,Yanan Yue,Dali Han,Xiao Wang,Ye Fu,Liang Zhang,Guifang Jia,Miao Yu,Zhike Lu,Xin Deng,Qing Dai,Weizhong Chen,Chuan He +12 more
TL;DR: It is reported here that human METTL14 catalyzes m6A RNA methylation, and together with METTL3, the only previously known m 6A methyltransferase, these two proteins form a stable heterodimer core complex ofMETTL3-14 that functions in cellular m6 a deposition on mammalian nuclear RNAs.
Journal ArticleDOI
RNA N6-methyladenosine methylation in post-transcriptional gene expression regulation
Yanan Yue,Jianzhao Liu,Chuan He +2 more
TL;DR: The broad roles of m(6)A in regulating cell fates and embryonic development highlight the existence of another layer of epigenetic regulation at the RNA level, where mRNA is subjected to chemical modifications that affect protein expression.
Journal ArticleDOI
VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation.
Yanan Yue,Jun Liu,Xiaolong Cui,Jie Cao,Guan-Zheng Luo,Zezhou Zhang,Tao Cheng,Minsong Gao,Xiao Shu,Honghui Ma,Fengqin Wang,Xinxia Wang,Bin Shen,Yizhen Wang,Xinhua Feng,Chuan He,Jianzhao Liu,Jianzhao Liu +17 more
TL;DR: A characterization of the full m6A methyltransferase complex in HeLa cells is reported identifying METTL3/METTL14/WTAP/VIRMA/HAKAI/ZC3H13 as the key components, and it is shown that VIRMA mediates preferential mRNA methylation in 3′UTR and near stop codon.
Journal ArticleDOI
Hyperbranched Conjugated Polysiloles: Synthesis, Structure, Aggregation-Enhanced Emission, Multicolor Fluorescent Photopatterning, and Superamplified Detection of Explosives
Jianzhao Liu,Yongchun Zhong,Jacky Wing Yip Lam,Ping Lu,Yuning Hong,Yong Yu,Yanan Yue,Mahtab Faisal,Herman H. Y. Sung,Ian D. Williams,Kam Sing Wong,Ben Zhong Tang,Ben Zhong Tang +12 more
TL;DR: In this article, hyperbranched poly(2,5-silole)s [hb-P1(m), m = 1, 6] are synthesized for the first time in this work.