Y
Yanchang Li
Researcher at Protein Sciences
Publications - 46
Citations - 487
Yanchang Li is an academic researcher from Protein Sciences. The author has contributed to research in topics: Proteome & Medicine. The author has an hindex of 13, co-authored 33 publications receiving 346 citations.
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Journal ArticleDOI
Enhanced Purification of Ubiquitinated Proteins by Engineered Tandem Hybrid Ubiquitin-binding Domains (ThUBDs)
Yuan Gao,Yanchang Li,Chengpu Zhang,Mingzhi Zhao,Chen Deng,Qiuyan Lan,Zexian Liu,Na Su,Jingwei Wang,Feng Xu,Yongru Xu,Lingyan Ping,Lei Chang,Gao Huiying,Junzhu Wu,Yu Xue,Zixin Deng,Junmin Peng,Ping Xu +18 more
TL;DR: ThUBD is a refined and promising approach for enriching the ubiquitinated proteome while circumventing the need to overexpress tagged ubiquitin variants and use antibodies to recognize ubiquitIn remnants, thus providing a readily accessible tool for the protein ubiquitination research community.
Journal ArticleDOI
Dimeric Ube2g2 simultaneously engages donor and acceptor ubiquitins to form Lys48-linked ubiquitin chains.
Weixiao Liu,Yongliang Shang,Yan Zeng,Chao Liu,Yanchang Li,Linhui Zhai,Pan Wang,Jizhong Lou,Ping Xu,Yihong Ye,Wei Li +10 more
TL;DR: An unanticipated mode of E2 self‐association that allows the E2 to effectively engage two ubiquitins to specifically synthesize Lys48‐linked ubiquitin chains is revealed.
Posted ContentDOI
Urine Proteome of COVID-19 Patients
Yanchang Li,Yihao Wang,Huiying Liu,Wei Sun,Baoqing Ding,Yinghua Zhao,Peiru Chen,Li Zhu,Zhaodi Li,Naikang Li,Lei Chang,Hengliang Wang,Changqing Bai,Ping Xu,Ping Xu +14 more
TL;DR: This study demonstrates the COVID-19 pathophysiology related molecular alterations could be detected in the urine and the potential application of urinary proteome in auxiliary diagnosis, severity determination and therapy development of CO VID-19.
Journal ArticleDOI
Quantitative Proteomics Reveals Membrane Protein-Mediated Hypersaline Sensitivity and Adaptation in Halophilic Nocardiopsis xinjiangensis.
Yao Zhang,Yao Zhang,Yanchang Li,Yongguang Zhang,Zhi Qiang Wang,Zhi Qiang Wang,Mingzhi Zhao,Na Su,Tao Zhang,Lingsheng Chen,Lingsheng Chen,Wei Wei,Jing Luo,Jing Luo,Yanxia Zhou,Yanxia Zhou,Yongru Xu,Yongru Xu,Ping Xu,Ping Xu,Ping Xu,Wen-Jun Li,Wen-Jun Li,Wen-Jun Li,Yong Tao +24 more
TL;DR: Overall, regulation of membrane proteins may provide a major protection strategy against hyperosmotic stress.
Journal ArticleDOI
Hepatitis B virus X induces inflammation and cancer in mice liver through dysregulation of cytoskeletal remodeling and lipid metabolism.
Zhongwei Xu,Linghui Zhai,Tailong Yi,Gao Huiying,Fengxu Fan,Yanchang Li,Youliang Wang,Ning Li,Xiaohua Xing,Na Su,Feilin Wu,Lei Chang,Xiuli Chen,Erhei Dai,Chao Zhao,Xiao Yang,Chunping Cui,Ping Xu +17 more
TL;DR: Evidence is provided that HBx induces the dysregulation of cytoskeleton remodeling and lipid metabolism and leads to the occurrence and development of liver cancer.