Yao Cong

TL;DR: This study provides a new insight into an unexpected autoinhibition and histone H3-induced activation of the de novo DNA methyltransferase after its initial genomic positioning and supports a negative correlation between H3K4me3 and DNA methylation across the mammalian genome.

TL;DR: This work integrates chemical crosslinking, mass spectrometry, and combinatorial modeling to reveal the definitive subunit arrangement of TRiC and explains all available crosslink experiments, provides a rationale for previously unexplained structural features, and reveals a surprising asymmetry of charges within the chaperonin folding chamber.

TL;DR: The findings depict the mechanism of ACE2-induced S trimer conformational transitions from the ground prefusion state toward the postfusion state, facilitating development of anti–SARS-CoV-2 vaccines and therapeutics.

TL;DR: The structure of the pore domain of MCU from Caenorhabditis elegans is determined using nuclear magnetic resonance (NMR) and electron microscopy, and this is one of the largest membrane protein structures characterized by NMR, and provides a structural blueprint for understanding the function of this channel.

TL;DR: Using electron cryo‐microscopy, the structure of an attenuated vaccine strain of VEEV is determined to 4.4 Å resolution, suggesting a mechanism for the initial stage of nucleocapsid core formation and shed light on the virulence attenuation, host recognition and neutralizing activities of V EEV and other alphavirus pathogens.