Yasushi Matsuki

TL;DR: It is shown that miRNAs are released through a ceramide-dependent secretory machinery and that the secretory miRNAAs are transferable and functional in the recipient cells and that a tumor-suppressive miRNA secreted via this pathway was transported between cells and exerted gene silencing in the recipients cells, thereby leading to cell growth inhibition.

TL;DR: A newly identified adipocytokine, visfatin, that is highly enriched in the visceral fat of both humans and mice and whose expression level in plasma increases during the development of obesity is isolated.

TL;DR: A newly identified adipocytokine, visfatin, that is highly enriched in the visceral fat of both humans and mice and whose expression level in plasma increases during the development of obesity is isolated.

TL;DR: It is indicated that vaspin exerts an insulin-sensitizing effect targeted toward WATs in states of obesity, which is similar to that of leptin, resistin, TNFalpha, glucose transporter-4, and adiponectin.

TL;DR: The results suggest that FSP27 contributes to efficient energy storage in WAT by promoting the formation of unilocular lipid droplets, thereby restricting lipolysis and finding that the nature of lipid accumulation in Wat appears to be associated with maintenance of energy balance and insulin sensitivity.