Showing papers by "Yi Yan Yang published in 2019"
TL;DR: Biodegradable triblock copolymers of PEG, guanidinium-functionalized polycarbonate and polylactide are designed as chemotherapeutic agents and show promise in the treatment of cancer without the onset of resistance.
42 citations
TL;DR: A degradable guanidinium-functionalized polycarbonate with unexpected antimicrobial activity and selectivity towards MDR Klebsiella pneumoniae is reported.
31 citations
TL;DR: This paper presents a strategy for the construction of macromolecular antimicrobial compounds using a catalyst-free, polyaddition polymerization process of monomers derived from poly(ethylene terephthalate) (PET) refuse.
Abstract: The discovery of antibiotics was one of the crowning achievements of the 20th century, revolutionizing the treatment of infectious disease. However, widespread improper use of antibiotics has led t...
28 citations
TL;DR: Antimicrobial polymers with a broad spectrum of action and high selectivity towards pathogens (versus mammalian cells) provide the opportunity to combat infections with only a limited chance of resistance development.
25 citations
TL;DR: It is hypothesized that tethering the surface of stem cells with colloidal particles capable of discharging antioxidant cargos in response to elevated levels of hydrogen peroxide would maintain survival and therapeutic activity of the stem cells.
24 citations
IBM1
TL;DR: These AMP-loaded nanoparticles have potential use for treatment of Parkinson's disease and were significantly accumulated in the brain tissue after intranasal delivery.
21 citations
IBM1
TL;DR: V Vitamin E- PEG-Vitamin E triblock 'ABA' hydrogel, which is formed through physical cross-linking of flower-shaped micelles and can reside in vivo for >17weeks, was employed for delivery of cancer preventive vaccines to provide sustained anticancer immunity.
19 citations
IBM1
TL;DR: A new series of vitamin E‐functionalized ‘ABA’ triblock copolymers with carbamate block junction, which can form hydrogen‐bonds, has potential for use as matrix for sustained delivery of antibodies.
17 citations
TL;DR: This study synthesized polyionenes based on quaternary ammonium salts consisting or amides or esters or amide/ester combinations that have broad spectrum of action against multiple classes of pathogens and exhibit low minimum inhibitor concentration (MIC).
17 citations
Patent•
26 Dec 2019TL;DR: In this article, an antimicrobial guanidinium macromolecule with one or more targeting moieties for selectively targeting bacteria is provided. But the method is not described.
Abstract: Compositions and methods regarding antimicrobial guanidinium macromolecules with one or more targeting moieties for selectively targeting bacteria are provided. According to an embodiment, an antimicrobial macromolecule is provided that comprises a polymer backbone and one or more guanidinium moieties that extend from the polymer backbone. The antimicrobial macromolecule further comprises a targeting moiety that extends from the polymer backbone. The targeting moiety can comprise a substance favored for consumption by bacteria, such as a monosaccharide.
3 citations
Patent•
06 Nov 2019TL;DR: In this article, a method of making an antifouling and bactericidal coating with tailorable surface topology was proposed, which includes depositing a layer of glyoxal in a water-containing solution on the layer of BPEI/PPO.
Abstract: Embodiments are directed to a method of making an antifouling and bactericidal coating with tailorable surface topology. The method includes depositing a layer of branched polyethyleneimine (BPEI) and diamino-functionalized poly(propylene oxide) (PPO) in a mixture of water and organic solvent on a substrate to form a layer of BPEI/PPO. The method includes depositing a layer of glyoxal in a water-containing solution on the layer of BPEI/PPO. The method further includes curing the layer of BPEI/PPO and layer of glyoxal to form a homogenous, glyoxal crosslinked BPEI/PPO coating, where the curing induces local precipitation and alteration of the glyoxal crosslinked BPEI/PPO coating to provide a textured surface.
TL;DR: An optimized PCS prototype was developed consisting of a newly designed stent, E2A membrane, and a three-slit pattern created by specific femtosecond laser cutting that preserved side-branch flow similar to physiological conditions in the flow experiment.
Abstract: Bare metal stenting (BMS) does not adequately address the atheroembolic characteristic of carotid artery stenosis. While simple covered stents (CS) may prevent dislodged fragments of the atheroscle...
Patent•
05 Aug 2019TL;DR: In this article, techniques regarding guanidinium functionalized polylysine polymers that can have antimicrobial and/or anticancer activity are provided, where one or more embodiments described in this paper can comprise a chemical composition, which can include a polymer comprising a molecular backbone covalently bonded to a pendent guanidine functional group.
Abstract: Techniques regarding guanidinium functionalized polylysine polymers that can have antimicrobial and/or anticancer activity are provided. For example, one or more embodiments described herein can comprise a chemical composition, which can comprise a polymer comprising a molecular backbone covalently bonded to a pendent guanidinium functional group, wherein the molecular backbone can comprise a polylysine structure.
Patent•
26 Dec 2019TL;DR: In this article, the antimicrobial guanidinium-functionalized polycarbonates that provide potent antimicrobial activity against multidrug resistant (MDR) bacteria, including Klebsiella pneumoniae (K. pneumoniae) are provided.
Abstract: Compositions and methods regarding guanidinium functionalized polycarbonates that provide potent antimicrobial activity against multidrug resistant (MDR) bacteria, including Klebsiella pneumoniae (K. pneumoniae) are provided. According to an embodiment, an antimicrobial guanidinium-functionalized polymer is provided that comprises a hydrophobic molecular backbone with cationic guanidinium moieties respectively bound to the hydrophobic molecular backbone via butyl spacer groups. The antimicrobial guanidinium-functionalized polymer self-assembles into a micelle structure with hydrophobic residuals of the antimicrobial guanidinium-functionalized polymer buried inside the micelle structure and the cationic guanidinium moieties exposed on an external surface of the micelle structure to target pathogens.
TL;DR: The successful delivery of apoptosis inducing proteins and sensitization of cancer cells via cationic bolaamphiphile polymer represents a promising system for cancer therapeutics.
Abstract: Cationic bolaamphiphile polymers had been previously studied as efficient delivery system for the delivery of proteins with relatively low toxicity. Here, the authors investigate the use of a protein delivery system based on a cationic bolaamphiphile to sensitize cancer cells toward apoptosis-inducing drugs as a novel approach for cancer therapy. The authors demonstrates the efficacy of the system by two strategies. The first strategy involves delivery of a survivin antibody to inhibit survivin activity. Sensitization of MCF-7 cells to doxorubicin is observed by survivin inhibition by antibodies. The IC50 of doxorubicin is reduced ≈2.5-fold after delivery of survivin antibodies to breast cancer cells and induction of apoptosis is shown by Western blotting with apoptosis specific antibodies. In a second approach, functional wild type p53 is delivered into p53-null liver cancer (Hep3B) cells, sensitizing the cells toward the p53 pathway drug, Nutlin. Nutlin reduced the viability of Hep3B cells by ≈42% at 15 μM concentration, demonstrating the effectiveness of p53 delivery. The expression of p21, a downstream target of p53 further confirmed the functional status of the delivered protein. In conclusion. The successful delivery of apoptosis inducing proteins and sensitization of cancer cells via cationic bolaamphiphile polymer represents a promising system for cancer therapeutics.
Patent•
05 Aug 2019TL;DR: In this article, a chemical composition comprising a polycarbonate polymer functionalized with a guanidinium functional group is described, which can also include an antirheumatic agent.
Abstract: Techniques regarding enhancing antimicrobial activity of antirheumatic agents by combination therapy are provided. For example, one or more embodiments described herein can regard a chemical composition comprising a polycarbonate polymer functionalized with a guanidinium functional group. The chemical composition can also comprise an antirheumatic agent, and the polycarbonate polymer can enhance an antimicrobial activity of the antirheumatic agent.