Showing papers in "Nanomedicine: Nanotechnology, Biology and Medicine in 2019"

TL;DR: The goal is to summarize the different approved nanoformulations on the market, and briefly cover the challenges and future outlook, and estimate the global nanomedicine market size and future growth.

TL;DR: In an Atherosclerosis model established in apolipoprotein E-deficient mice, PNP encapsulating rapamycin significantly attenuated the progression of atherosclerosis and stabilized atherosclerotic plaques and demonstrated the perfect efficacy and pro-resolving potential of PNP as a targeted drug delivery platform for atheros sclerosis treatment.

TL;DR: Biosynthesized nanoparticles indicated interesting biological properties and should be subjected to further research to establish their pharmacological relevance.

TL;DR: Different classes of virus-like particles and caged protein nanoparticles that have been used as vehicles to transport and increase the interaction of cancer vaccine components with the immune system are discussed.

TL;DR: Utility of SERS spectral signature for deciphering exosomal surface signature is identified for detection of pancreatic cancer.

TL;DR: To amplify the effectiveness of nano-based approach in a conquest against NiV, a list of developed nanosystem with antiviral activity is also a prerequisite, and the present review provides a meticulous cognizance of cellular and molecular pathogenesis of NiV.

TL;DR: UF led to higher protein, lipid, cytokine and exosomes yields compared with UC, and a secretome dosage was identified to obtain the same immunomodulatory activity of MSCs, paving the way for cell-free therapy.

TL;DR: relevant physiological processes involved in vaccine delivery are highlighted, recent advances in the use of nanoparticle systems for vaccines are reviewed, and pertinent challenges to viably translate nanoparticle-based vaccines and adjuvants for public use are discussed.

TL;DR: The newly discovered CRISPR-Cas14 possesses a single-stranded (ss)DNA targeting activity - despite being two times smaller than Cas9 - a capability that might confer a defense against viruses with ssDNA genomes.

TL;DR: This review highlights the recent progress of nanoscale MOFs as drug delivery vehicles for cancer theranostics and identifies areas of research that it believes will propel the translation and application of MOFs.

TL;DR: This article is the first systematic review of the effects of biosynthesized nanoparticles on both malaria parasites (Plasmodium spp.) and relevant vectors and presents current knowledge about the characterization and effectiveness of biogenic NPs against major vectors of malaria, including avian malaria.

TL;DR: It was demonstrated that C60UHFM are a novel antioxidant and radioprotective agent capable of substantial reduction of the harmful effects of ionizing radiation.

TL;DR: A SpyCatcher-modified ferritin nanoparticle platform is established, which permits convenient and stable covalent conjugation with tumor specific antigens containing SpyTag in a click-link manner, especially for personalized tumor immunotherapy.

TL;DR: G4HisMal can be considered as a promising drug candidate to prevent Alzheimer disease via synapse protection and a maltose-histidine shell can be used to improve biocompatibility and ability to cross the blood-brain barrier of dendrimers.

TL;DR: DBP-PLGA nanoparticles could be a promising therapeutic candidate for the treatment of AD, according to the results suggest.

TL;DR: The application of L-DOPA-AuNFs as a non-inflammatory BBB-penetrating nanovehicle to efficiently deliver therapies into the brain to develop vehicles which efficiently penetrate the blood-brain barrier.

TL;DR: The evolution of biomaterial approaches from cell-based therapies to induce immune tolerance with a focus on the Tolerogenic Immune-Modifying nanoParticle (TIMP) platform, which can be designed to treat various autoimmune conditions and is currently in clinical trials testing its ability to reverse celiac disease.

TL;DR: GC-TP-NP represents a promising candidate in halting liver cancer progression while minimizing systemic toxicity, and induced cancer cell apoptosis via blocking TNF/NF-κB/BCL2 signaling.

TL;DR: It is important to understand the fundamental biological processes that govern endosomal escape in order to design more effective therapeutic delivery systems.

TL;DR: The system achieved the synergistic trimodal chemotherapeutic/photothermal/photodynamic treatment and demonstrated excellent antitumor effect, which is expected to have a greater potential for cancer therapy.

TL;DR: The contribution of fluorescence imaging in exploring the fate of NPs in biological systems is discussed, and NP applications for in vivo imaging, including cell labeling, multimodal imaging and theranostic agents are discussed.

TL;DR: The experiments in vitro and in vivo demonstrate that colloidal TiO2 nanoparticles could significantly suppress the growth of osteosarcomas, even under low power (5 W) microwave (MW) irradiation for 5 min.

TL;DR: The effect of femtosecond laser nanotexturing of surfaces of Ti6Al4V and Zr implants on their biological compatibility is presented and discussed and the effect of protein adsorption from blood plasma on cell proliferation is discussed.

TL;DR: Recent progress in the development of nano PTX formulations by various pharmaceutical companies for safe and effective drug therapies for patients benefit is provided.

TL;DR: This manuscript describes the comparison between the traditional extrusion method to microfluidics, the new paradigm in liposome production and scale-up and shows how the fine control of process parameters results in improved reproducibility between batches.

TL;DR: It is shown that a combination of two size-based methods using a 0.20μm syringe filter and 100 k centrifuge membrane filter followed by ultracentrifugation yields a greater number of uniform exosomes, and that the distribution was dependent on the exosomal protein/cytokine contents.

TL;DR: The strategies available for evaluation of genotoxicity of nanoparticles (NPs) are reviewed, current status of silica nanoparticle gene alteration and genot toxicity is surveyed, particle-mediated inflammation as a contributing factor togenotoxicity is discussed, existing gaps are identified and future directions are suggested.

TL;DR: The results showed that the 3D printed osteochondral scaffold design successfully promoted osteogenic and chondrogenic differentiation of human bone marrow mesenchymal stem cells, as well as enhanced gene expression associated with both osteogenesis andChondrogenesis alike.

TL;DR: Folic acid and BSA decorated gold nanoclusters can be effective radiosensitizers for intracranial glioma tumors RT and the gliomas-bearing rats' survival times were almost doubled at radiation therapy + FA-AuNCs.

TL;DR: Cl-PEG-pSL showed rapid endo/lysosome-escape abilities in the cancer cells and higher tumor accumulation in MIA PaCa-2 xenograft model in contrast to PEG- pSL.