Y
Yi Yan Yang
Researcher at Agency for Science, Technology and Research
Publications - 374
Citations - 22011
Yi Yan Yang is an academic researcher from Agency for Science, Technology and Research. The author has contributed to research in topics: Micelle & Antimicrobial. The author has an hindex of 75, co-authored 358 publications receiving 19328 citations. Previous affiliations of Yi Yan Yang include National University of Singapore & Imperial College London.
Papers
More filters
Journal ArticleDOI
POE/PLGA composite microspheres: formation and in vitro behavior of double walled microspheres.
TL;DR: It was found that compared to the neat POE or PLGA microspheres, distinct degradation mechanism was achieved in the double walled POE/PLGA micro Spheres system and kept more than 32% of its initial molecular weight over a period of 7 weeks.
Journal ArticleDOI
Injectable Coacervate Hydrogel for Delivery of Anticancer Drug-Loaded Nanoparticles in vivo
Ashlynn L. Z. Lee,Zhi Xiang Voo,Willy Chin,Robert J. Ono,Chuan Yang,Shujun Gao,James L. Hedrick,Yi Yan Yang +7 more
TL;DR: In vivo studies performed in a multiple myeloma MM.1S xenograft mouse model showed that the tumor progression of mice treated withBTZ-loaded micelle solution was similar to that of the control group, whereas those treated with the BTZ- loaded micelle/hydrogel composite resulted in significant delay in the tumors progression.
Journal ArticleDOI
Hydrophilic Polycarbonates: Promising Degradable Alternatives to Poly(ethylene glycol)-Based Stealth Materials
Amanda C. Engler,Xiyu Ke,Shujun Gao,Julian M. W. Chan,Daniel J. Coady,Robert J. Ono,Roy Lubbers,Roy Lubbers,Alshakim Nelson,Yi Yan Yang,James L. Hedrick +10 more
TL;DR: Water-soluble, nonfouling polycarbonates, prepared by acid-catalyzed ring-opening polymerization, contain hydroxyl groups attached to the polymer side chain via an amide linkage offer an enzymatically and hydrolytically degradable alternative to PEG.
Journal ArticleDOI
Synergistic Anticancer Effects Achieved by Co‐Delivery of TRAIL and Paclitaxel Using Cationic Polymeric Micelles
TL;DR: Cationic micellar nanoparticles self-assembled from a biodegradable amphiphilic copolymer have been used to deliver human TRAIL and paclitaxel simultaneously and induces synergistic anti-cancer activities with limited toxicity in non-cancerous cells.
Journal ArticleDOI
Structure-directing star-shaped block copolymers: supramolecular vesicles for the delivery of anticancer drugs.
Chuan Yang,Shaoqiong Liu,Shrinivas Venkataraman,Shujun Gao,Xiyu Ke,Xin Tian Chia,James L. Hedrick,Yi Yan Yang +7 more
TL;DR: The unique ability of the star-like copolymer emanating from the methyl cholate core provided the requisite modification in the blockCopolymer interfacial curvature to generate vesicles of high loading capacity for DOX with significant kinetic stability that have potential for use as an anti-cancer drug delivery carrier for cancer therapy.