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Yi Yan Yang
Researcher at Agency for Science, Technology and Research
Publications - 374
Citations - 22011
Yi Yan Yang is an academic researcher from Agency for Science, Technology and Research. The author has contributed to research in topics: Micelle & Antimicrobial. The author has an hindex of 75, co-authored 358 publications receiving 19328 citations. Previous affiliations of Yi Yan Yang include National University of Singapore & Imperial College London.
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Mathematical modeling and in vitro study of controlled drug release via a highly swellable and dissoluble polymer matrix: polyethylene oxide with high molecular weights.
TL;DR: The overall drug release process is found to be highly dependent on the matrix swelling, drug and water diffusion, polymer dissolution and initial dimensions of the tablets, and predicts with a very good agreement with experimental data at different initial loadings.
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Biodegradable poly(ethylene glycol)-peptide hydrogels with well-defined structure and properties for cell delivery.
TL;DR: Biodegradable PEG-peptide hydrogels synthesized using Click chemistry may provide a platform technology to deliver cells for tissue repair and explore the possibility of using the RGD peptidehydrogels for cell-based wound healing.
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The role of non-covalent interactions in anticancer drug loading and kinetic stability of polymeric micelles.
Chuan Yang,Amalina Binte Ebrahim Attia,Jeremy P. K. Tan,Xiyu Ke,Shujun Gao,James L. Hedrick,Yi Yan Yang +6 more
TL;DR: Among all the polymers synthesized in this study, 1b with 8 acid/urea groups in the random form had the optimum properties, indicating that 1b micelles may be a promising carrier for delivery of anticancer drugs that contain amine groups.
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Broad‐Spectrum Antimicrobial and Biofilm‐Disrupting Hydrogels: Stereocomplex‐Driven Supramolecular Assemblies
Yan Li,Kazuki Fukushima,Daniel J. Coady,Amanda C. Engler,Shaoqiong Liu,Yuan Huang,John S. Cho,Yi Guo,Lloyd S. Miller,Jeremy P. K. Tan,Pui Lai Rachel Ee,Weimin Fan,Yi Yan Yang,James L. Hedrick +13 more
TL;DR: These hydrogels with hierarchical nanostructures were made with broad-spectrum antimicrobial activities and biofilm-disruption capability have great potential for clinical use in prevention and treatment of various multidrug-resistant infections.
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Targeted and intracellular delivery of paclitaxel using multi-functional polymeric micelles.
TL;DR: It was demonstrated that the micelles exhibited a useful pH-induced thermo-sensitivity, such that drug was released more rapidly at pH 5.0 (acidic endosomal/lysosomal environment) than at pH 7.4 (normal extracellular pH).