S
Shao Chun Wang
Researcher at China Medical University (Taiwan)
Publications - 85
Citations - 5223
Shao Chun Wang is an academic researcher from China Medical University (Taiwan). The author has contributed to research in topics: Cancer & Cancer cell. The author has an hindex of 35, co-authored 84 publications receiving 4427 citations. Previous affiliations of Shao Chun Wang include Jining Medical University & University of Texas MD Anderson Cancer Center.
Papers
More filters
Journal ArticleDOI
Imparting functionality to biocatalysts via embedding enzymes into nanoporous materials by a de novo approach: size-selective sheltering of catalase in metal-organic framework microcrystals.
Fa Kuen Shieh,Shao Chun Wang,Chia I. Yen,Chang Cheng Wu,Saikat Dutta,Lien-Yang Chou,Joseph V. Morabito,Pan Hu,Ming Hua Hsu,Kevin C.-W. Wu,Chia-Kuang Tsung +10 more
TL;DR: Because catalase is immobilized and sheltered by the ZIF-90 crystals, the composites show activity in hydrogen peroxide degradation even in the presence of protease proteinase K.
Journal ArticleDOI
Tyrosine phosphorylation controls PCNA function through protein stability.
Shao Chun Wang,Yusuke Nakajima,Yusuke Nakajima,Yung Luen Yu,Weiya Xia,Chun Te Chen,Cheng Chieh Yang,Eric W. McIntush,Long Yuan Li,Long Yuan Li,David H. Hawke,Ryuji Kobayashi,Mien Chie Hung +12 more
TL;DR: A novel nuclear mechanism linking tyrosine kinase receptor function with the regulation of the PCNA sliding clamp is identified, which is better correlated with poor survival of breast cancer patients, as well as nuclear EGFR in tumours, than is the total PCNA level.
Journal ArticleDOI
Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB-2
Shao Chun Wang,Huang-Chun Lien,Weiya Xia,I. Fen Chen,Hui-Wen Lo,Zhiqin Wang,Mohamed Ali-Seyed,Dung Fang Lee,Dung Fang Lee,Geoffrey Bartholomeusz,Fu Ou-Yang,Dipak Giri,Mien Chie Hung +12 more
TL;DR: It is reported that ErbB-2 is also expressed in the nucleus in cultured cells as well as primary tumor tissues and the function of Erb B-2 as a transcriptional regulator is identified.
Journal ArticleDOI
Shielding against Unfolding by Embedding Enzymes in Metal–Organic Frameworks via a de Novo Approach
Fu Siang Liao,Wei Shang Lo,Yu Shen Hsu,Chang Cheng Wu,Shao Chun Wang,Fa Kuen Shieh,Joseph V. Morabito,Lien-Yang Chou,Kevin C.-W. Wu,Chia-Kuang Tsung +9 more
TL;DR: In this article, an enzyme maintains its biological function under a wider range of conditions after being embedded in metal-organic framework (MOF) microcrystals via a de novo approach.
Journal ArticleDOI
Endosomal transport of ErbB-2: mechanism for nuclear entry of the cell surface receptor.
Dipak Giri,Mohamed Ali-Seyed,Long Yuan Li,Dung Fang Lee,Pin Ling,Geoffrey Bartholomeusz,Shao Chun Wang,Mien Chie Hung +7 more
TL;DR: A novel mechanism that involves interaction with the transport receptor importin β1, nuclear pore protein Nup358, and a host of players in endocytic internalization explains how a receptor tyrosine kinase on the cell surface can be translocated into the nucleus.