N
Nicola D. Kerrison
Researcher at University of Cambridge
Publications - 43
Citations - 2872
Nicola D. Kerrison is an academic researcher from University of Cambridge. The author has contributed to research in topics: Population & Genome-wide association study. The author has an hindex of 19, co-authored 36 publications receiving 1793 citations.
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Journal ArticleDOI
An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans
Robert A. Scott,Laura J. Scott,Reedik Mägi,Letizia Marullo,Kyle J. Gaulton,Kyle J. Gaulton,Marika Kaakinen,Natalia Pervjakova,Tune H. Pers,Andrew D. Johnson,John D. Eicher,Anne U. Jackson,Teresa Ferreira,Yeji Lee,Clement Ma,Valgerdur Steinthorsdottir,Gudmar Thorleifsson,Lu Qi,Lu Qi,Natalie R. van Zuydam,Natalie R. van Zuydam,Anubha Mahajan,Han Chen,Peter Almgren,B F Voight,Harald Grallert,Martina Müller-Nurasyid,Janina S. Ried,Nigel W. Rayner,Nigel W. Rayner,Nigel W. Rayner,Neil Robertson,Neil Robertson,Lennart C. Karssen,Elisabeth M. van Leeuwen,Sara M. Willems,Sara M. Willems,Christian Fuchsberger,Phoenix Kwan,Tanya M. Teslovich,Pritam Chanda,Man Li,Yingchang Lu,Christian Dina,Dorothée Thuillier,Loic Yengo,Longda Jiang,Thomas Sparsø,Hans A. Kestler,Hans A. Kestler,Himanshu Chheda,Lewin Eisele,Stefan Gustafsson,Mattias Frånberg,Mattias Frånberg,Mattias Frånberg,Rona J. Strawbridge,Rafn Benediktsson,Astradur B. Hreidarsson,Augustine Kong,Gunnar Sigurðsson,Nicola D. Kerrison,Jian'an Luan,Liming Liang,Thomas Meitinger,Michael Roden,Barbara Thorand,Tõnu Esko,Tõnu Esko,Tõnu Esko,Evelin Mihailov,Caroline S. Fox,Ching-Ti Liu,Denis Rybin,Bo Isomaa,Valeriya Lyssenko,Tiinamaija Tuomi,David Couper,James S. Pankow,Niels Grarup,Christian Theil Have,Marit E. Jørgensen,Torben Jørgensen,Torben Jørgensen,Allan Linneberg,Allan Linneberg,Marilyn C. Cornelis,Rob M. van Dam,Rob M. van Dam,David J. Hunter,Peter Kraft,Qi Sun,Qi Sun,Sarah Edkins,Katharine R. Owen,Katharine R. Owen,John R. B. Perry,Andrew R. Wood,Eleftheria Zeggini,Juan Tajes-Fernandes,Gonçalo R. Abecasis,Lori L. Bonnycastle,Peter S. Chines,Heather M. Stringham,Heikki A. Koistinen,Heikki A. Koistinen,Heikki A. Koistinen,Leena Kinnunen,Leena Kinnunen,Leena Kinnunen,Bengt Sennblad,Bengt Sennblad,Thomas W. Mühleisen,Markus M. Nöthen,Sonali Pechlivanis,Damiano Baldassarre,Karl Gertow,Steve E. Humphries,Elena Tremoli,Norman Klopp,Julia Meyer,Gerald Steinbach,Roman Wennauer,Johan G. Eriksson,Satu Mӓnnistö,Leena Peltonen,Emmi Tikkanen,Guillaume Charpentier,E. Eury,Stéphane Lobbens,Bruna Gigante,Karin Leander,Olga McLeod,Erwin P. Bottinger,Omri Gottesman,Douglas M. Ruderfer,Matthias Blüher,Peter Kovacs,Anke Tönjes,Nisa M. Maruthur,Chiara Scapoli,Raimund Erbel,Karl-Heinz Jöckel,Susanne Moebus,Ulf de Faire,Anders Hamsten,Michael Stumvoll,Panagiotis Deloukas,Panagiotis Deloukas,Peter Donnelly,Peter Donnelly,Timothy M. Frayling,Andrew T. Hattersley,Samuli Ripatti,Veikko Salomaa,Nancy L. Pedersen,Bernhard O. Boehm,Richard N. Bergman,Francis S. Collins,Karen L. Mohlke,Jaakko Tuomilehto,Torben Hansen,Torben Hansen,Oluf Pedersen,Inês Barroso,Inês Barroso,Lars Lannfelt,Erik Ingelsson,Erik Ingelsson,Lars Lind,Cecilia M. Lindgren,Cecilia M. Lindgren,Stéphane Cauchi,Philippe Froguel,Philippe Froguel,Ruth J. F. Loos,Beverley Balkau,Beverley Balkau,Heiner Boeing,Paul W. Franks,Paul W. Franks,Aurelio Barricarte Gurrea,Domenico Palli,Yvonne T. van der Schouw,David Altshuler,Leif Groop,Leif Groop,Claudia Langenberg,Nicholas J. Wareham,Eric J.G. Sijbrands,Cornelia M. van Duijn,Jose C. Florez,Jose C. Florez,James B. Meigs,James B. Meigs,Eric Boerwinkle,Eric Boerwinkle,Christian Gieger,Konstantin Strauch,Andres Metspalu,Andrew D. Morris,Colin N. A. Palmer,Frank B. Hu,Frank B. Hu,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Kari Stefansson,Kari Stefansson,Josée Dupuis,Andrew P. Morris,Michael Boehnke,Mark I. McCarthy,Mark I. McCarthy,Mark I. McCarthy,Inga Prokopenko,Inga Prokopenko,Inga Prokopenko +216 more
TL;DR: This article conducted a meta-analysis of genome-wide association data from 26,676 T2D case and 132,532 control subjects of European ancestry after imputation using the 1000 Genomes multiethnic reference panel.
Journal ArticleDOI
Gene-lifestyle interaction and type 2 diabetes: the EPIC interact case-cohort study.
Claudia Langenberg,Stephen J. Sharp,Paul W. Franks,Robert A. Scott,Panos Deloukas,Nita G. Forouhi,Philippe Froguel,Leif Groop,Torben Hansen,Luigi Palla,Oluf Pedersen,Matthias B. Schulze,María José Tormo,Eleanor Wheeler,Claudia Agnoli,L. Arriola,Aurelio Barricarte,Heiner Boeing,Geraldine M. Clarke,Françoise Clavel-Chapelon,Eric J. Duell,Guy Fagherazzi,Rudolf Kaaks,Nicola D. Kerrison,Timothy J. Key,Kay-Tee Khaw,Janine Kröger,Martin Lajous,Andrew P. Morris,Carmen Navarro,Peter M. Nilsson,Kim Overvad,Domenico Palli,Salvatore Panico,J. Ramón Quirós,Olov Rolandsson,Carlotta Sacerdote,María José Sánchez,Nadia Slimani,Annemieke M.W. Spijkerman,Rosario Tumino,Daphne L. van der A,Yvonne T. van der Schouw,Inês Barroso,Mark I. McCarthy,Elio Riboli,Nicholas J. Wareham +46 more
TL;DR: The authors found that the relative effect of a type 2 diabetes genetic risk score is greater in younger and leaner participants, and the high absolute risk associated with obesity at any level of genetic risk highlights the importance of universal rather than targeted approaches to lifestyle intervention.
Journal ArticleDOI
Validity of a short questionnaire to assess physical activity in 10 European countries
Tricia M. Peters,Soren Brage,Kate Westgate,Paul W. Franks,Paul W. Franks,Anna Gradmark,María José Tormo Díaz,José María Huerta,Benedetta Bendinelli,Mattheaus Vigl,Heiner Boeing,Wanda Wendel-Vos,Annemieke M.W. Spijkerman,Kristin Benjaminsen-Borch,Elisavet Valanou,Blandine De Lauzon Guillain,Françoise Clavel-Chapelon,Stephen J. Sharp,Nicola D. Kerrison,Claudia Langenberg,Larraitz Arriola,Aurelio Barricarte,Carlos A. Gonzales,Sara Grioni,Rudolf Kaaks,Timothy J. Key,Kay-Tee Khaw,A. M. May,Peter M. Nilsson,Teresa Norat,Kim Overvad,Domenico Palli,Salvatore Panico,José Ramón Quirós,Fulvio Ricceri,María José Sánchez,Nadia Slimani,Anne Tjønneland,Rosario Tumino,Edith J. M. Feskens,Elio Riboli,Ulf Ekelund,Nicholas J. Wareham +42 more
TL;DR: The validity of a brief PA questionnaire used in the European Prospective Investigation into Cancer and Nutrition (EPIC) is examined, finding the EPIC-PAQ is suitable for categorizing European men and women into four distinct categories of overall physical activity.
Journal ArticleDOI
Long-term risk of incident type 2 diabetes and measures of overall and regional obesity: the EPIC-InterAct case-cohort study.
Claudia Langenberg,Stephen J. Sharp,Matthias B. Schulze,Olov Rolandsson,Kim Overvad,Nita G. Forouhi,Joachim Spranger,Dagmar Drogan,José María Huerta,Larraitz Arriola,Blandine de Lauzon-Guillan,Blandine de Lauzon-Guillan,María José Tormo,Eva Ardanaz,Beverley Balkau,Beverley Balkau,Joline W.J. Beulens,Heiner Boeing,H. Bas Bueno-de-Mesquita,Françoise Clavel-Chapelon,Francesca L. Crowe,Paul W. Franks,Carlos González,Sara Grioni,Jytte Halkjær,Göran Hallmans,Rudolf Kaaks,Nicola D. Kerrison,Timothy J. Key,Kay-Tee Khaw,Amalia Mattiello,Peter M. Nilsson,Teresa Norat,Luigi Palla,Domenico Palli,Salvatore Panico,J. Ramón Quirós,Dora Romaguera,Isabelle Romieu,Carlotta Sacerdote,María José Sánchez,Nadia Slimani,Ivonne Sluijs,Annemieke M.W. Spijkerman,Birgit Teucher,Anne Tjønneland,Rosario Tumino,L. van der A. Daphne,Yvonne T. van der Schouw,Edith J. M. Feskens,Elio Riboli,Nicholas J. Wareham +51 more
TL;DR: A collaborative re-analysis of data from the InterAct case-control study has established that waist circumference is associated with risk of type 2 diabetes, independently of body mass index.
Journal ArticleDOI
Human Gain-of-Function MC4R Variants Show Signaling Bias and Protect against Obesity
Luca A. Lotta,Jacek Mokrosinski,Edson Mendes de Oliveira,Chen Li,Stephen J. Sharp,Jian'an Luan,Bas Brouwers,Vikram Ayinampudi,Nicholas Bowker,Nicola D. Kerrison,Vasileios Kaimakis,Diana Hoult,Isobel D. Stewart,Eleanor Wheeler,Felix R. Day,John R. B. Perry,Claudia Langenberg,Nicholas J. Wareham,I. Sadaf Farooqi +18 more
TL;DR: Protective associations were driven by MC4R variants exhibiting signaling bias toward β-arrestin recruitment and increased mitogen-activated protein kinase pathway activation, which may represent an effective strategy for weight loss and the treatment of obesity-related cardiometabolic diseases.