Y
Ying Hu
Researcher at National Institutes of Health
Publications - 181
Citations - 17475
Ying Hu is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Cancer & Gene. The author has an hindex of 46, co-authored 156 publications receiving 14842 citations. Previous affiliations of Ying Hu include University of Maryland, Baltimore & Thomas Jefferson University.
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Journal ArticleDOI
Allelotyping of esophageal squamous-cell carcinoma on chromosome 13 defines deletions related to family history.
Nan Hu,Hua Su,Wen-Jun Li,Carol Giffen,Alisa M. Goldstein,Ying Hu,Chaoyu Wang,Mark J. Roth,Guang Li,Sanford M. Dawsey,Yi Xu,Philip R. Taylor,Michael R. Emmert-Buck +12 more
TL;DR: Analysis of allelic loss data sets from patients with and without a family history of upper gastrointestinal tumors indicates that a gene or genes on chromosome 13 play an important role in the etiology and progression of ESCC.
Journal ArticleDOI
Necdin is a breast cancer metastasis suppressor that regulates the transcription of c-Myc
Minnkyong Lee,Sarah M. Beggs,Derek Gildea,Sujata Bupp,Jens Lichtenberg,Niraj S. Trivedi,Nisc Comparative Sequencing Program,Ying Hu,David M. Bodine,Nigel P.S. Crawford +9 more
TL;DR: Haplotype analysis in a well-characterized breast cancer cohort revealed thatNDN germline variation is associated with both NDN expression levels and patient outcome, and ChIP assays demonstrate that NDN and the T50C allele regulate gene expression and metastasis efficiency.
Journal ArticleDOI
Genetic background may contribute to PAM50 gene expression breast cancer subtype assignments.
Ying Hu,Ling Bai,Thomas R. Geiger,Natalie Goldberger,Renard C. Walker,Jeffery E. Green,Lalage M. Wakefield,Kent W. Hunter +7 more
TL;DR: Using a genetically engineered mouse mammary tumor model, it is demonstrated that the PAM50 subtype signature of tumors driven by a common oncogenic event can be significantly influenced by the genetic background on which the tumor arises.
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GGPS1 Mutations Cause Muscular Dystrophy/Hearing Loss/Ovarian Insufficiency Syndrome
A. Reghan Foley,Yaqun Zou,James E. Dunford,Jachinta Rooney,Goutam Chandra,Hui Xiong,Volker Straub,Thomas Voit,Norma B. Romero,Sandra Donkervoort,Ying Hu,Thomas C. Markello,Adam Horn,Leila Qebibo,Jahannaz Dastgir,Jahannaz Dastgir,Katherine G. Meilleur,Katherine G. Meilleur,Richard S. Finkel,Richard S. Finkel,Yanbin Fan,Kamel Mamchaoui,Stephanie Duguez,Stephanie Duguez,Isabelle Nelson,Jocelyn Laporte,Mariarita Santi,Edoardo Malfatti,Thierry Maisonobe,Philippe Touraine,Michio Hirano,Imelda Hughes,Kate Bushby,Udo Oppermann,Udo Oppermann,Udo Oppermann,Johann Böhm,Jyoti K. Jaiswal,Tanya Stojkovic,Carsten G. Bönnemann +39 more
TL;DR: A hitherto undescribed phenotype of early onset muscular dystrophy associated with sensorineural hearing loss and primary ovarian insufficiency was initially identified in 2 siblings and in subsequent patients with a similar constellation of findings.
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The potential of sphingomyelin as a chemopreventive agent in AOM-induced colon cancer model: wild-type and p53+/- mice
TL;DR: While increasing intestinal SMase activity and suppressing proliferation, SM did not promote any form of apoptosis and failed to achieve significant protection in these mice and further investigation to understand the variable effect of SM in preventing CRC is warranted.