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Ying Nai Wang
Researcher at University of Texas MD Anderson Cancer Center
Publications - 53
Citations - 2772
Ying Nai Wang is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Receptor tyrosine kinase & Epidermal growth factor receptor. The author has an hindex of 24, co-authored 47 publications receiving 2276 citations. Previous affiliations of Ying Nai Wang include National Cheng Kung University & Asia University (Taiwan).
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Journal ArticleDOI
Nuclear trafficking of the epidermal growth factor receptor family membrane proteins
TL;DR: The putative mechanisms by which EGFR family RTKs are shuttled into the nucleus are discussed, which will significantly contribute to understanding the functions of the nuclearRTKs.
Journal ArticleDOI
Removal of N-Linked Glycosylation Enhances PD-L1 Detection and Predicts Anti-PD-1/PD-L1 Therapeutic Efficacy
Heng Huan Lee,Ying Nai Wang,Wei Ya Xia,Chia-Hung Chen,Kun Ming Rau,Leiguang Ye,Yongkun Wei,Chao Kai Chou,Shao Chun Wang,Meisi Yan,Meisi Yan,Chih Yen Tu,Te Chun Hsia,Shu Fen Chiang,K. S. Clifford Chao,Ignacio I. Wistuba,Jennifer L. Hsu,Jennifer L. Hsu,Jennifer L. Hsu,Gabriel N. Hortobagyi,Mien Chie Hung +20 more
TL;DR: A method to resolve this by removing the glycan moieties from cell surface antigens via enzymatic digestion, a process termed sample deglycosylation, significantly improves anti-PD-L1 antibody binding affinity and signal intensity, resulting in more accurate PD-L 1 quantification and prediction of clinical outcome.
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Crosstalk between Arg 1175 methylation and Tyr 1173 phosphorylation negatively modulates EGFR-mediated ERK activation
Jung Mao Hsu,Chun Te Chen,Chun Te Chen,Chao Kai Chou,Chao Kai Chou,Hsu Ping Kuo,Hsu Ping Kuo,Long Yuan Li,Chun Yi Lin,Hong Jen Lee,Hong Jen Lee,Ying Nai Wang,Mo Liu,Mo Liu,Hsin Wei Liao,Hsin Wei Liao,Bin Shi,Chien-Chen Lai,Mark T. Bedford,Chang Hai Tsai,Chang Hai Tsai,Mien Chie Hung +21 more
TL;DR: A model in which the regulatory crosstalk between PRMT5-mediated Arg 1175 methylation and EGF-induced Tyr 1173 phosphorylation attenuates EGFR-mediated ERK activation is proposed.
Journal ArticleDOI
Nuclear epidermal growth factor receptor (EGFR) interacts with signal transducer and activator of transcription 5 (STAT5) in activating Aurora-A gene expression
Liang Yi Hung,Joseph T. Tseng,Yi Chao Lee,Weiya Xia,Ying Nai Wang,Min Li Wu,Yu Hsuan Chuang,Chein Hsien Lai,Wen Chang Chang +8 more
TL;DR: This study proposes that the nuclear EGFR associates with STAT5 to bind and increase Aurora-A gene expression, which ultimately may lead to chromosome instability and tumorigenesis.
Journal ArticleDOI
Nuclear Translocation of Epidermal Growth Factor Receptor by Akt-dependent Phosphorylation Enhances Breast Cancer-resistant Protein Expression in Gefitinib-resistant Cells
Wei Chien Huang,Yun Ju Chen,Long Yuan Li,Ya Ling Wei,Sheng Chieh Hsu,Shing Ling Tsai,Pei Chun Chiu,Wei-Pang Huang,Ying Nai Wang,Chung-Hsuan Chen,Wei Chao Chang,Wei Chao Chang,Wen Chang Chang,Andy Jer En Chen,Chang Hai Tsai,Chang Hai Tsai,Mien Chie Hung,Mien Chie Hung +17 more
TL;DR: Light is shed on the role of nuclear EGFR in the sensitivity of wtEGFR-expressing cancer cells to EGFR tyrosine kinase inhibitors and a putative molecular mechanism contributing to gefitinib resistance through BCRP/ABCG2 expression is deciphered.