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Yun Ju Chen
Researcher at I-Shou University
Publications - 36
Citations - 1044
Yun Ju Chen is an academic researcher from I-Shou University. The author has contributed to research in topics: Lapatinib & Epidermal growth factor receptor. The author has an hindex of 17, co-authored 33 publications receiving 904 citations. Previous affiliations of Yun Ju Chen include National Cheng Kung University & Asia University (Taiwan).
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Journal ArticleDOI
Nuclear Translocation of Epidermal Growth Factor Receptor by Akt-dependent Phosphorylation Enhances Breast Cancer-resistant Protein Expression in Gefitinib-resistant Cells
Wei Chien Huang,Yun Ju Chen,Long Yuan Li,Ya Ling Wei,Sheng Chieh Hsu,Shing Ling Tsai,Pei Chun Chiu,Wei-Pang Huang,Ying Nai Wang,Chung-Hsuan Chen,Wei Chao Chang,Wei Chao Chang,Wen Chang Chang,Andy Jer En Chen,Chang Hai Tsai,Chang Hai Tsai,Mien Chie Hung,Mien Chie Hung +17 more
TL;DR: Light is shed on the role of nuclear EGFR in the sensitivity of wtEGFR-expressing cancer cells to EGFR tyrosine kinase inhibitors and a putative molecular mechanism contributing to gefitinib resistance through BCRP/ABCG2 expression is deciphered.
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APOBEC3G promotes liver metastasis in an orthotopic mouse model of colorectal cancer and predicts human hepatic metastasis
Qingqing Ding,Chun Ju Chang,Xiaoming Xie,Weiya Xia,Jer Yen Yang,Jer Yen Yang,Shao Chun Wang,Yan Wang,Jiahong Xia,Libo Chen,Changchung Cai,Huabin Li,Chia Jui Yen,Hsu-Ping Kuo,Hsu-Ping Kuo,Dung Fang Lee,Dung Fang Lee,Jingyu Lang,Longfei Huo,Xiaoyun Cheng,Xiaoyun Cheng,Yun Ju Chen,Chia Wei Li,Long Bin Jeng,Jennifer L. Hsu,Long Yuan Li,Alai Tan,Steven A. Curley,Lee M. Ellis,Raymond N. DuBois,Mien Chie Hung +30 more
TL;DR: Key factors and mechanisms involved in colorectal cancer liver metastasis are elucidated, which could be potential targets for diagnosis and treatment.
Journal ArticleDOI
Elevated BCRP/ABCG2 Expression Confers Acquired Resistance to Gefitinib in Wild-Type EGFR-Expressing Cells
Yun Ju Chen,Wei Chien Huang,Ya Ling Wei,Sheng Chieh Hsu,Ping Yuan,Heather Lin,Ignacio I. Wistuba,J. Jack Lee,Chia Jui Yen,Wu Chou Su,Kwang Yu Chang,Wen Chang Chang,Tse-Chuan Chou,Tse-Chuan Chou,Chao Kai Chou,Chang Hai Tsai,Chang Hai Tsai,Mien Chie Hung +17 more
TL;DR: It is shown that acquired resistance of wtEGFR-expressing cancer cells to an EGFR TKI, gefitinib, is associated with elevated expression of breast cancer resistance protein (BCRP/ABCG2), which in turn leads to gefITinib efflux from cells.
Journal ArticleDOI
ERK2-mediated C-terminal serine phosphorylation of p300 is vital to the regulation of epidermal growth factor-induced keratin 16 gene expression
TL;DR: Results strongly suggested that the ERK2-mediated C-terminal serine phosphorylation of p300 was a key event in the regulation of EGF-induced keratin 16 expression.
Journal ArticleDOI
BCRP/ABCG2 Inhibition Sensitizes Hepatocellular Carcinoma Cells to Sorafenib
Wei Chien Huang,Yi Ling Hsieh,Chao Ming Hung,Pei Hsuan Chien,Yu Fong Chien,Lei Chin Chen,Chih Yen Tu,Chia-Hung Chen,Sheng Chieh Hsu,Yueh Ming Lin,Yun Ju Chen +10 more
TL;DR: Results suggest not only that BCRP/ABCG2 is a potential predictor for the sorafenib sensitivity in HCC, but also that blockage of B CRP/ ABCG2 may be a potential strategy to increase the response of HCC cells to sorafinib.