L
Long Yuan Li
Researcher at National Chung Hsing University
Publications - 57
Citations - 5517
Long Yuan Li is an academic researcher from National Chung Hsing University. The author has contributed to research in topics: Cancer & Phosphorylation. The author has an hindex of 30, co-authored 55 publications receiving 5016 citations. Previous affiliations of Long Yuan Li include National Defense Medical Center & China Medical University (Taiwan).
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Journal ArticleDOI
ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation
Jer Yen Yang,Cong S. Zong,Weiya Xia,Hirohito Yamaguchi,Qingqing Ding,Xiaoming Xie,Jingyu Lang,Chien-Chen Lai,Chun Ju Chang,Wei Chien Huang,Hsin Huang,Hsu-Ping Kuo,Hsu-Ping Kuo,Dung Fang Lee,Dung Fang Lee,Long Yuan Li,Long Yuan Li,Huang-Chun Lien,Xiaoyun Cheng,Xiaoyun Cheng,King-Jen Chang,Chwan-Deng Hsiao,Fuu Jen Tsai,Chang Hai Tsai,Chang Hai Tsai,Aysegul A. Sahin,William J. Muller,Gordon B. Mills,Dihua Yu,Gabriel N. Hortobagyi,Mien Chie Hung +30 more
TL;DR: This study elucidates a novel pathway in cell growth and tumorigenesis through negative regulation of FOXO3a by RAS–ERK and MDM2 and downregulates Forkhead box O 3a by directly interacting with and phosphorylating FOXO 3a at Ser 294, Ser 344 and Ser 425.
Journal ArticleDOI
IKKβ Suppression of TSC1 Links Inflammation and Tumor Angiogenesis via the mTOR Pathway
Dung Fang Lee,Hsu Ping Kuo,Hsu Ping Kuo,Chun Te Chen,Chun Te Chen,Jung Mao Hsu,Jung Mao Hsu,Chao Kai Chou,Chao Kai Chou,Yongkun Wei,Hui-Lung Sun,Long Yuan Li,Long Yuan Li,Long Yuan Li,Bo Ping,Wei Chien Huang,Xianghuo He,Jen Yu Hung,Chien-Chen Lai,Qingqing Ding,Jen Liang Su,Jer Yen Yang,Jer Yen Yang,Aysegul A. Sahin,Gabriel N. Hortobagyi,Fuu Jen Tsai,Chang Hai Tsai,Chang Hai Tsai,Mien Chie Hung +28 more
TL;DR: It is shown that IKKbeta, a major downstream kinase in the TNFalpha signaling pathway, physically interacts with and phosphorylates TSC1 at Ser487 and Ser511, resulting in suppression of T SC1 and activates the mTOR pathway, enhances angiogenesis, and results in tumor development.
Journal ArticleDOI
Degradation of Mcl-1 by β-TrCP Mediates Glycogen Synthase Kinase 3-Induced Tumor Suppression and Chemosensitization
Qingqing Ding,Xianghuo He,Jung Mao Hsu,Jung Mao Hsu,Weiya Xia,Chun Te Chen,Chun Te Chen,Long Yuan Li,Long Yuan Li,Long Yuan Li,Dung Fang Lee,Dung Fang Lee,Jaw Ching Liu,Qing Zhong,Xiaodong Wang,Mien Chie Hung +15 more
TL;DR: It is reported that glycogen synthase kinase 3 (GSK-3) was required for Mcl-1 degradation, and a novel mechanism for proteasome-mediated M cl-1 turnover was identified, which is an essential mechanism for GSK-3β-induced apoptosis and contributes to G SKS-3 β-mediated tumor suppression and chemosensitization.
Journal ArticleDOI
Regulation of Tumor Angiogenesis by EZH2
Chunhua Lu,Hee Dong Han,Lingegowda S. Mangala,Rouba Ali-Fehmi,Christopher S. Newton,Laurent Ozbun,Guillermo N. Armaiz-Pena,Wei Hu,Rebecca L. Stone,Adnan R. Munkarah,Murali Ravoori,Mian M.K. Shahzad,Mian M.K. Shahzad,Jeong Won Lee,Jeong Won Lee,Edna M. Mora,Edna M. Mora,Robert R. Langley,Amy R. Carroll,Koji Matsuo,Whitney A. Spannuth,Rosemarie Schmandt,Nicholas B. Jennings,Blake W. Goodman,Robert B. Jaffe,Alpa M. Nick,Hye Sun Kim,Hye Sun Kim,Eylem Güven,Ya Huey Chen,Long Yuan Li,Long Yuan Li,Ming Chuan Hsu,Robert L. Coleman,George A. Calin,Emir Baki Denkbaş,Jae Yun Lim,Ju Seog Lee,Vikas Kundra,Michael J. Birrer,Mien Chie Hung,Mien Chie Hung,Gabriel Lopez-Berestein,Anil K. Sood +43 more
TL;DR: It is shown that increased Zeste homolog 2 (EZH2) expression in either tumor cells or in tumor vasculature is predictive of poor clinical outcome, and the potential for targeting ezh2 as an important therapeutic approach is supported.
Journal ArticleDOI
CDK1-dependent phosphorylation of EZH2 suppresses methylation of H3K27 and promotes osteogenic differentiation of human mesenchymal stem cells.
Yongkun Wei,Ya Huey Chen,Long Yuan Li,Long Yuan Li,Jingyu Lang,Su-Peng Yeh,Bin Shi,Cheng Chieh Yang,Jer Yen Yang,Chun Yi Lin,Chien-Chen Lai,Chien-Chen Lai,Mien Chie Hung +12 more
TL;DR: It is demonstrated that EZH2 can be phosphorylated at Thr 487 through activation of cyclin-dependent kinase 1 (CDK1) and defined a signalling link between CDK1 and EZh2 that may have an important role in diverse biological processes, including cancer-cell invasion and osteogenic differentiation of mesenchymal stem cells.