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Yiqi Huang
Researcher at Technische Universität München
Publications - 8
Citations - 808
Yiqi Huang is an academic researcher from Technische Universität München. The author has contributed to research in topics: Proteome & Proteomics. The author has an hindex of 3, co-authored 5 publications receiving 322 citations.
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Journal ArticleDOI
Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.
Alexey Stukalov,Virginie Girault,Vincent Grass,Ozge Karayel,Valter Bergant,Christian Urban,Darya A. Haas,Yiqi Huang,Lila Oubraham,Anqi Wang,M. Sabri Hamad,Antonio Piras,Fynn M. Hansen,Maria C. Tanzer,Igor Paron,Luca Zinzula,Thomas Engleitner,Maria Reinecke,Maria Reinecke,Teresa M. Lavacca,Rosina Ehmann,Roman Wölfel,Jörg Jores,Bernhard Kuster,Bernhard Kuster,Ulrike Protzer,Roland Rad,John Ziebuhr,Volker Thiel,Pietro Scaturro,Pietro Scaturro,Matthias Mann,Andreas Pichlmair +32 more
TL;DR: A concurrent multi-omics study of SARS CoV-2 and SARS-CoV was conducted in this article, where the authors profiled the interactomes of both viruses, as well as their influence on the transcriptome, proteome, ubiquitinome and phosphoproteome of a lung derived human cell line.
Posted ContentDOI
Multi-level proteomics reveals host-perturbation strategies of SARS-CoV-2 and SARS-CoV
Alexey Stukalov,Virginie Girault,Vincent Grass,Ozge Karayel,Valter Bergant,Christian Urban,Darya A. Haas,Yiqi Huang,Lila Oubraham,Anqi Wang,Sabri M. Hamad,Antonio Piras,Fynn M. Hansen,Maria C. Tanzer,Igor Paron,Luca Zinzula,Luca Zinzula,Thomas Engleitner,Maria Reinecke,Maria Reinecke,Teresa M. Lavacca,Rosina Ehmann,Roman Wölfel,Jörg Jores,Bernhard Kuster,Bernhard Kuster,Ulrike Protzer,Roland Rad,John Ziebuhr,Volker Thiel,Pietro Scaturro,Pietro Scaturro,Matthias Mann,Andreas Pichlmair +33 more
TL;DR: The TGF-β pathway, known for its involvement in tissue fibrosis, was specifically dysregulated by Sars-CoV-2 ORF8 and autophagy by SARS-CoVs ORF3, and was identified as a hotspot that can be targeted by existing drugs and it can guide rational design of virus- and host-directed therapies.
Posted ContentDOI
Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV
Alexey Stukalov,Virginie Girault,Vincent Grass,Ozge Karayel,Valter Bergant,Christian Urban,Darya A. Haas,Yiqi Huang,Lila Oubraham,Anqi Wang,M. Sabri Hamad,Antonio Piras,Fynn M. Hansen,Maria C. Tanzer,Igor Paron,Luca Zinzula,Thomas Enghleitner,Maria Reinecke,Maria Reinecke,Teresa M. Lavacca,Rosina Ehmann,Roman Wölfel,Jörg Jores,Bernhard Kuster,Bernhard Kuster,Ulrike Protzer,Roland Rad,John Ziebuhr,Volker Thiel,Pietro Scaturro,Pietro Scaturro,Matthias Mann,Andreas Pichlmair +32 more
TL;DR: In this paper, the authors conducted a concurrent multi-omics study of SARS-CoV-2 and SARS CoV, and profiled the interactome of both viruses, as well as their influence on transcriptome, proteome, ubiquitinome and phosphoproteome in a lung-derived human cell line.
Journal ArticleDOI
Single-cell RNA sequencing reveals ex vivo signatures of SARS-CoV-2-reactive T cells through 'reverse phenotyping'.
David S. Fischer,Meshal Ansari,Karolin I. Wagner,Sebastian Jarosch,Yiqi Huang,Christoph H. Mayr,Maximilian Strunz,Niklas J. Lang,Elvira D’Ippolito,Monika Hammel,Laura Mateyka,Simone Weber,Lisa S. Wolff,K. Witter,Isis E. Fernandez,Gabriela Leuschner,Katrin Milger,Marion Frankenberger,Lorenz Nowak,Katharina Heinig-Menhard,Ina Koch,Mircea Gabriel Stoleriu,Anne Hilgendorff,Jürgen Behr,Andreas Pichlmair,Benjamin Schubert,Fabian J. Theis,Dirk H. Busch,Dirk H. Busch,Herbert B. Schiller,Kilian Schober +30 more
TL;DR: In this paper, single-cell RNA sequencing was used to identify and profile SARS-CoV-2-reactive T cells from Coronavirus Disease 2019 (COVID-19) patients.
Posted ContentDOI
Single-cell RNA sequencing reveals in vivo signatures of SARS-CoV-2-reactive T cells through 'reverse phenotyping'
David S. Fischer,Meshal Ansari,Karolin I. Wagner,Sebastian Jarosch,Yiqi Huang,Christoph H. Mayr,Maximilian Strunz,Niklas J. Lang,Elvira D’Ippolito,Monika Hammel,Laura Mateyka,Simone Weber,Lisa S. Wolff,K. Witter,Isis E. Fernandez,Gabriela Leuschner,Kathrin Milger,Marion Frankenberger,Lorenz Nowak,Katharina Heinig-Menhard,Ina Koch,Mircea Gabriel Stoleriu,Anne Hilgendorff,Jürgen Behr,Andreas Pichlmair,Andreas Pichlmair,Benjamin Schubert,Fabian J. Theis,Dirk H. Busch,Dirk H. Busch,Herbert B. Schiller,Kilian Schober +31 more
TL;DR: Single-cell RNA sequencing is used to identify and profile SARS-CoV-2-reactive T cells from Coronavirus Disease 2019 (COVID-19) patients and take advantage of natural T cell receptor (TCR) sequences of clonally expanded T cells as barcodes for 'reverse phenotyping'.