F
Fynn M. Hansen
Researcher at Max Planck Society
Publications - 20
Citations - 1041
Fynn M. Hansen is an academic researcher from Max Planck Society. The author has contributed to research in topics: Proteomics & Proteome. The author has an hindex of 6, co-authored 16 publications receiving 398 citations.
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Journal ArticleDOI
Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.
Alexey Stukalov,Virginie Girault,Vincent Grass,Ozge Karayel,Valter Bergant,Christian Urban,Darya A. Haas,Yiqi Huang,Lila Oubraham,Anqi Wang,M. Sabri Hamad,Antonio Piras,Fynn M. Hansen,Maria C. Tanzer,Igor Paron,Luca Zinzula,Thomas Engleitner,Maria Reinecke,Maria Reinecke,Teresa M. Lavacca,Rosina Ehmann,Roman Wölfel,Jörg Jores,Bernhard Kuster,Bernhard Kuster,Ulrike Protzer,Roland Rad,John Ziebuhr,Volker Thiel,Pietro Scaturro,Pietro Scaturro,Matthias Mann,Andreas Pichlmair +32 more
TL;DR: A concurrent multi-omics study of SARS CoV-2 and SARS-CoV was conducted in this article, where the authors profiled the interactomes of both viruses, as well as their influence on the transcriptome, proteome, ubiquitinome and phosphoproteome of a lung derived human cell line.
Posted ContentDOI
Multi-level proteomics reveals host-perturbation strategies of SARS-CoV-2 and SARS-CoV
Alexey Stukalov,Virginie Girault,Vincent Grass,Ozge Karayel,Valter Bergant,Christian Urban,Darya A. Haas,Yiqi Huang,Lila Oubraham,Anqi Wang,Sabri M. Hamad,Antonio Piras,Fynn M. Hansen,Maria C. Tanzer,Igor Paron,Luca Zinzula,Luca Zinzula,Thomas Engleitner,Maria Reinecke,Maria Reinecke,Teresa M. Lavacca,Rosina Ehmann,Roman Wölfel,Jörg Jores,Bernhard Kuster,Bernhard Kuster,Ulrike Protzer,Roland Rad,John Ziebuhr,Volker Thiel,Pietro Scaturro,Pietro Scaturro,Matthias Mann,Andreas Pichlmair +33 more
TL;DR: The TGF-β pathway, known for its involvement in tissue fibrosis, was specifically dysregulated by Sars-CoV-2 ORF8 and autophagy by SARS-CoVs ORF3, and was identified as a hotspot that can be targeted by existing drugs and it can guide rational design of virus- and host-directed therapies.
Posted ContentDOI
Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV
Alexey Stukalov,Virginie Girault,Vincent Grass,Ozge Karayel,Valter Bergant,Christian Urban,Darya A. Haas,Yiqi Huang,Lila Oubraham,Anqi Wang,M. Sabri Hamad,Antonio Piras,Fynn M. Hansen,Maria C. Tanzer,Igor Paron,Luca Zinzula,Thomas Enghleitner,Maria Reinecke,Maria Reinecke,Teresa M. Lavacca,Rosina Ehmann,Roman Wölfel,Jörg Jores,Bernhard Kuster,Bernhard Kuster,Ulrike Protzer,Roland Rad,John Ziebuhr,Volker Thiel,Pietro Scaturro,Pietro Scaturro,Matthias Mann,Andreas Pichlmair +32 more
TL;DR: In this paper, the authors conducted a concurrent multi-omics study of SARS-CoV-2 and SARS CoV, and profiled the interactome of both viruses, as well as their influence on transcriptome, proteome, ubiquitinome and phosphoproteome in a lung-derived human cell line.
Journal ArticleDOI
Interconversion between Anticipatory and Active GID E3 Ubiquitin Ligase Conformations via Metabolically Driven Substrate Receptor Assembly.
Shuai Qiao,Christine R. Langlois,Jakub Chrustowicz,Dawafuti Sherpa,Ozge Karayel,Fynn M. Hansen,Viola Beier,Susanne von Gronau,Daniel Bollschweiler,Tillman Schafer,Arno F. Alpi,Matthias Mann,J.R. Prabu,Brenda A. Schulman +13 more
TL;DR: In this paper, the authors define molecular underpinnings of glucose-induced degradation and reveal evolutionarily conserved GID complexes as a family of multisubunit E3 ubiquitin ligases responsive to extracellular stimuli.
Journal ArticleDOI
Data-independent acquisition method for ubiquitinome analysis reveals regulation of circadian biology.
Fynn M. Hansen,Maria C. Tanzer,Franziska Brüning,Franziska Brüning,Isabell Bludau,Che A. Stafford,Brenda A. Schulman,Maria S. Robles,Ozge Karayel,Matthias Mann +9 more
TL;DR: In this article, the authors developed a sensitive workflow combining diGly antibody-based enrichment and optimized Orbitrap-based DIA with comprehensive spectral libraries together containing more than 90,000 peptides.