Teresa M. Lavacca

TL;DR: A concurrent multi-omics study of SARS CoV-2 and SARS-CoV was conducted in this article, where the authors profiled the interactomes of both viruses, as well as their influence on the transcriptome, proteome, ubiquitinome and phosphoproteome of a lung derived human cell line.

TL;DR: The TGF-β pathway, known for its involvement in tissue fibrosis, was specifically dysregulated by Sars-CoV-2 ORF8 and autophagy by SARS-CoVs ORF3, and was identified as a hotspot that can be targeted by existing drugs and it can guide rational design of virus- and host-directed therapies.

TL;DR: In this paper, the authors conducted a concurrent multi-omics study of SARS-CoV-2 and SARS CoV, and profiled the interactome of both viruses, as well as their influence on transcriptome, proteome, ubiquitinome and phosphoproteome in a lung-derived human cell line.

TL;DR: This paper used an affinity proteomics approach in evolutionary distant species (human, mouse and fly) to identify proteins that are conserved in their ability to associate with diverse viral nucleic acids.

TL;DR: It is found that the host cap 2'‐O‐ribose methyl transferase MTr1 can compensate for loss of viral NSP16 methyltransferase in facilitating virus replication, and multispecific and metabolic MTase inhibitors constitute yet unexplored treatment options against COVID‐19.