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Yogesh Saletore
Researcher at Cornell University
Publications - 9
Citations - 5097
Yogesh Saletore is an academic researcher from Cornell University. The author has contributed to research in topics: Gene & RNA. The author has an hindex of 9, co-authored 9 publications receiving 3661 citations. Previous affiliations of Yogesh Saletore include Max Planck Society.
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Journal ArticleDOI
Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons
Kate D. Meyer,Yogesh Saletore,Paul Zumbo,Olivier Elemento,Christopher E. Mason,Samie R. Jaffrey +5 more
TL;DR: A method is presented for transcriptome-wide m(6)A localization, which combines m( 6)A-specific methylated RNA immunoprecipitation with next-generation sequencing (MeRIP-Seq) and reveals insights into the epigenetic regulation of the mammalian transcriptome.
Journal ArticleDOI
The N 6 -methyladenosine (m 6 A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells
Ly P. Vu,Brian F. Pickering,Yuanming Cheng,Sara Zaccara,Diu T.T. Nguyen,Gerard Minuesa,Timothy Chou,Arthur Chow,Yogesh Saletore,Matthew MacKay,Jessica Schulman,Christopher Famulare,Minal Patel,Virginia M. Klimek,Francine E. Garrett-Bakelman,Ari Melnick,Martin Carroll,Christopher E. Mason,Samie R. Jaffrey,Michael G. Kharas +19 more
TL;DR: It is shown that shRNA-mediated depletion of the m6A-forming enzyme METTL3 in human hematopoietic stem/progenitor cells (HSPCs) promotes cell differentiation, coupled with reduced cell proliferation, and this results provide a rationale for the therapeutic targeting of MET TL3 in myeloid leukemia.
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The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry
Martin E. Hess,Simon Hess,Kate D. Meyer,Linda A W Verhagen,Linda Koch,Hella S. Brönneke,Marcelo O. Dietrich,Sabine D. Jordan,Yogesh Saletore,Olivier Elemento,Bengt F. Belgardt,Thomas Franz,Tamas L Horvath,Ulrich Rüther,Samie R. Jaffrey,Peter Kloppenburg,Jens C. Brüning +16 more
TL;DR: It is demonstrated that inactivation of the Fto gene, encoding a nucleic acid demethylase, impairs dopamine receptor type 2 (D2R) and type 3 (D3R) (collectively, 'D2-like receptor')-dependent control of neuronal activity and behavioral responses.
Journal ArticleDOI
The birth of the Epitranscriptome: deciphering the function of RNA modifications
Yogesh Saletore,Kate D. Meyer,Jonas Korlach,Igor D. Vilfan,Samie R. Jaffrey,Christopher E. Mason +5 more
TL;DR: A perspective on current work and new single-molecule sequencing methods for detecting RNA base modifications is presented, and methyl-6-adenosine is shown to be most pronounced near the beginning of the 3' UTR.
Journal ArticleDOI
Dynamics of the human and viral m 6 A RNA methylomes during HIV-1 infection of T cells
Gianluigi Lichinchi,Gianluigi Lichinchi,Shang Gao,Yogesh Saletore,Gwendolyn Gonzalez,Vikas Bansal,Yinsheng Wang,Christopher E. Mason,Tariq M. Rana,Tariq M. Rana +9 more
TL;DR: It is shown that viral infection triggers a massive increase in m6A in both host and viral mRNAs, which identifies a new mechanism for the control of HIV-1 replication and its interaction with the host immune system.