Francine E. Garrett-Bakelman

TL;DR: An R package that rapidly analyzes genome-wide cytosine epigenetic profiles from high-throughput methylation and Hydroxymethylation sequencing experiments is described, which includes functions for clustering, sample quality visualization, differential methylation analysis and annotation features, thus automating and simplifying many of the steps for discerning statistically significant bases or regions of DNAmethylation.

TL;DR: It is shown that shRNA-mediated depletion of the m6A-forming enzyme METTL3 in human hematopoietic stem/progenitor cells (HSPCs) promotes cell differentiation, coupled with reduced cell proliferation, and this results provide a rationale for the therapeutic targeting of MET TL3 in myeloid leukemia.

TL;DR: Given that the majority of the biological and human health variables remained stable, or returned to baseline, after a 340-day space mission, these data suggest that human health can be mostly sustained over this duration of spaceflight.

TL;DR: It is observed that epigenetic allele burden is linked to inferior outcome and varies considerably during disease progression, and genetic and epigenetic heterogeneity can occur with distinct kinetics likely to affect the biological and clinical features of tumors.

TL;DR: An enhanced form of reduced representation bisulfite sequencing with extended genomic coverage was developed, which resulted in greater capture of DNA methylation information of regions lying outside of traditional CpG islands, which demonstrated that genetically distinct AML subtypes display diametrically opposedDNA methylation patterns.