Yoshiki Yamaguchi

TL;DR: This review provides an overview of crystallographic analyses of glycoproteins, in which electron density of the glycan moiety is clearly observed, and suggests the more mobile N-glycans on cell surface receptors seem to guide the partner ligand to its binding site and prevent irregular protein aggregation by covering oligomerization sites away from the ligand-binding site.

TL;DR: P24 complexes act as cargo receptors for sorting GPI-anchored proteins into COPII vesicles and have shown the ability to modulate the GPI/COPII chiral reprograming process.

TL;DR: The ability of RNA aptamers to recognize--and bind to--human IgG with high specificity and affinity is demonstrated, and an optimized 23-nucleotide aptamer, Apt8-2, was shown to bind to the Fc domain of human IgG, but not to other IgG's, with high affinity.

TL;DR: Interaction analysis of 2b with CRT was measured by 1H NMR spectroscopy, and the first NMR-based evidence for the specific binding of CRT to 2b was obtained.

TL;DR: To elucidate the structural basis of the glycan-dependent and independent interactions, comparative crystallographic studies of podoplanin and rhodocytin in complex with CLEC-2 reveal unique and versatile binding modes that open a way to understand the functional consequences of CLEC -2-ligand interactions.