Y
Yoshiki Yamaguchi
Researcher at Tohoku Pharmaceutical University
Publications - 270
Citations - 7268
Yoshiki Yamaguchi is an academic researcher from Tohoku Pharmaceutical University. The author has contributed to research in topics: Glycan & Glycosylation. The author has an hindex of 41, co-authored 247 publications receiving 6186 citations. Previous affiliations of Yoshiki Yamaguchi include University of Tokyo & Max Planck Society.
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Journal ArticleDOI
NMR and mutational identification of the collagen-binding site of the chaperone Hsp47.
Maho Yagi-Utsumi,Maho Yagi-Utsumi,Sumi Yoshikawa,Yoshiki Yamaguchi,Yohei Nishi,Eiji Kurimoto,Eiji Kurimoto,Yoshihito Ishida,Takayuki Homma,Jun Hoseki,Yoshimi Nishikawa,Takaki Koide,Kazuhiro Nagata,Koichi Kato,Koichi Kato +14 more
TL;DR: An NMR study is conducted to identify the collagen-binding site of heat shock protein 47 and provides a molecular basis for the design of compounds that target the interaction between Hsp47 and procollagen as therapeutics for fibrotic diseases.
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Short disordered protein segment regulates cross-species transmission of a yeast prion.
Toshinobu Shida,Yuji O. Kamatari,Takao Yoda,Yoshiki Yamaguchi,Michael Feig,Yumiko Ohhashi,Yumiko Ohhashi,Yuji Sugita,Kazuo Kuwata,Motomasa Tanaka +9 more
TL;DR: The findings uncover how conformational dynamics of the short segment in the host prion protein impacts cross-species prion transmission and provides mechanistic insights into cross-seeding between heterologous proteins.
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Novel missense mutation in DLL4 in a Japanese sporadic case of Adams-Oliver syndrome.
Miwako Nagasaka,Mariko Taniguchi-Ikeda,Hidehito Inagaki,Yuya Ouchi,Daisuke Kurokawa,Keiji Yamana,Risa Harada,Kandai Nozu,Yoshitada Sakai,Sushil Kumar Mishra,Yoshiki Yamaguchi,Ichiro Morioka,Tatsushi Toda,Hiroki Kurahashi,Kazumoto Iijima +14 more
TL;DR: The case described here showed gradual recovery from skull defects after birth and no psychomotor developmental delay has been observed, and this is the second report of an AOS case with DLL4 mutation, and the phenotypic characteristics between the two cases are compared and discussed.
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Mode of substrate recognition by the Josephin domain of ataxin‐3, which has an endo‐type deubiquitinase activity
Tadashi Satoh,Akira Sumiyoshi,Maho Yagi-Utsumi,Eri Sakata,Hiroaki Sasakawa,Eiji Kurimoto,Yoshiki Yamaguchi,Wei Li,Claudio A. P. Joazeiro,Takatsugu Hirokawa,Koichi Kato,Koichi Kato +11 more
TL;DR: NMR data obtained following site‐specific paramagnetic spin labeling of Lys48‐linked di‐ubiquitin revealed that both ubiquitin units interact with the Josephin domain, with the C‐terminal Gly76 of the proximal unit being situated in the vicinity of the catalytic triad of Josephindomain.
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Synthesis of the Core Oligosaccharides of Lipooligosaccharides from Campylobacter jejuni: A Putative Cause of Guillain-Barré Syndrome.
Fumi Yoshida,Hiroki Yoshinaka,Hidenori Tanaka,Shinya Hanashima,Yoshiki Yamaguchi,Mikio Ishihara,Miyuki Saburomaru,Yuki Kato,Risa Saito,Hiromune Ando,Makoto Kiso,Akihiro Imamura,Hideharu Ishida +12 more
TL;DR: All synthetic blocks were constructed through a convergent synthetic route, which resulted in the first synthesis of structurally challenging LOS core glycans containing ganglioside GM1 and GD1a-core sequences.