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Yoshiki Yamaguchi

Researcher at Tohoku Pharmaceutical University

Publications -  270
Citations -  7268

Yoshiki Yamaguchi is an academic researcher from Tohoku Pharmaceutical University. The author has contributed to research in topics: Glycan & Glycosylation. The author has an hindex of 41, co-authored 247 publications receiving 6186 citations. Previous affiliations of Yoshiki Yamaguchi include University of Tokyo & Max Planck Society.

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Synthesis of a biotinylated keratan sulfate tetrasaccharide composed of dimeric Galβ1-4GlcNAc6Sβ

TL;DR: The subsequent chemoselective removal of the protecting group at O-6 of two GlcNAcs, sulfation, and deprotection procedures as well as biotinylation gave the target compound.
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Oxidative Stress: 1,5-Diazacyclooctanes, as Exclusive Oxidative Polyamine Metabolites, Inhibit Amyloid-β(1-40) Fibrillization (Adv. Sci. 10/2016)

TL;DR: The results suggest that polyamine/acrolein conjugates are involved in the neutralization and modulation of neuro‐degeneration process, and thus that polyamines and acroleins may have both harmful and beneficial effects in the body.
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Hydrogen Bonding Makes a Difference in the Rhodium-Catalyzed Enantioselective Hydrogenation Using Monodentate Phosphoramidites.

TL;DR: In this paper, a new generation of monodentate phosphoramidite ligands bearing a primary amine moiety was found to display comparable or better efficiency than bisphosphines in the Rh-catalyzed asymmetric hydrogenation of challenging substrates, affording the corresponding hydrogenation products with excellent enantioselectivities.