CA : A Cancer Journal for Clinicians

Objective To address terminology and other issues related to thyroid fine-needle aspiration (FNA), the National Cancer Institute (NCI) hosted The NCI Thyroid FNA State of the Science Conference. The conclusions regarding terminology and morphologic criteria from the NCI meeting led to the Bethesda Thyroid Atlas Project and form the framework for the Bethesda System for Reporting Thyroid Cytopathology. Design Participants of the Atlas Project were selected from among the committee members of the NCI FNA State of the Science Conference and other participants at the live conference. The terminology framework was based on a literature search of English language publications dating back to 1995 using PubMed as the search engine; online forum discussions ( http://thyroidfna.cancer.gov/forums/default.aspx ); and formal interdisciplinary discussions held on October 22 and 23, 2007, in Bethesda, MD. Main outcome For clarity of communication, the Bethesda System for Reporting Thyroid Cytopathology recommends that each report begin with one of the six general diagnostic categories. Each of the categories has an implied cancer risk that links it to an appropriate clinical management guideline. Conclusions The project participants hope that the adoption of this framework will facilitate communication among cytopathologists, endocrinologists, surgeons, and radiologists; facilitate cytologic-histologic correlation for thyroid diseases; facilitate research into the understanding of thyroid diseases; and allow easy and reliable sharing of data from different laboratories for national and international collaborative studies.

The Bethesda System for Reporting Thyroid Cytopathology.

Summary Background Compared with open resection, laparoscopic resection of rectal cancers is associated with improved short-term outcomes, but high-level evidence showing similar long-term outcomes is scarce. We aimed to compare survival outcomes of laparoscopic surgery with open surgery for patients with mid-rectal or low-rectal cancer. Methods The Comparison of Open versus laparoscopic surgery for mid or low REctal cancer After Neoadjuvant chemoradiotherapy (COREAN) trial was an open-label, non-inferiority, randomised controlled trial done between April 4, 2006, and Aug 26, 2009, at three centres in Korea. Patients (aged 18–80 years) with cT3N0–2M0 mid-rectal or low-rectal cancer who had received preoperative chemoradiotherapy were randomly assigned (1:1) to receive either open or laparoscopic surgery. Randomisation was stratified by sex and preoperative chemotherapy regimen. Investigators were masked to the randomisation sequence; patients and clinicians were not masked to the treatment assignments. The primary endpoint was 3 year disease-free survival, with a non-inferiority margin of 15%. Analysis was by intention to treat. This trial is registered with ClinicalTrials.gov, number NCT00470951. Findings We randomly assigned 340 patients to receive either open surgery (n=170) or laparoscopic surgery (n=170). 3 year disease-free survival was 72·5% (95% CI 65·0–78·6) for the open surgery group and 79·2% (72·3–84·6) for the laparoscopic surgery group, with a difference that was lower than the prespecified non-inferiority margin (–6·7%, 95% CI −15·8 to 2·4; p Interpretation Our results show that laparoscopic resection for locally advanced rectal cancer after preoperative chemoradiotherapy provides similar outcomes for disease-free survival as open resection, thus justifying its use. Funding National Cancer Center, South Korea.

https://www.thelancet.com/pdfs/journals/lanonc/PIIS1470-2045(14)70205-0.pdf

Open versus laparoscopic surgery for mid-rectal or low-rectal cancer after neoadjuvant chemoradiotherapy (COREAN trial): survival outcomes of an open-label, non-inferiority, randomised controlled trial.

Objective:To determine the safety of laparoscopy-assisted distal gastrectomy (LADG) compared with open distal gastrectomy (ODG) in patients with clinical stage I gastric cancer in Korea.Background:There is still a lack of large-scale, multicenter randomized trials regarding the safety of LADG.Method

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Decreased Morbidity of Laparoscopic Distal Gastrectomy Compared With Open Distal Gastrectomy for Stage I Gastric Cancer: Short-term Outcomes From a Multicenter Randomized Controlled Trial (KLASS-01).

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The Foundations Of Differential Geometry

Purpose: The purpose of our study was to compare the outcomes of patients who had undergone a conventional open adrenalectomy (OA) with those who had undergone a laparoscopic adrenalectomy (LA) Methods: We retrospectively reviewed 66 patients who underwent an adrenalectomy between 1990 and 2005 The study group was comprised of 41 laparoscopic cases with 25 open adrenalectomy cases comprising the control group The parameters studied included the operating times, transfusion volumes, time to resumption of a soft diet, total frequency of analgesics, time to return to free ambulation and length of hospital stay in both the OA and LA groups Results: No mortality was observed in either the OA or LA groups The operating times were, on average, 2031645 and 1582764 minutes in the OA and LA group, respectively (P=0011) 10 cases in the OA group needed a transfusion (average: 4385268757 ml), but two cases including one require conversion to a celiotomy, due to a right renal vein injury, needed a transfusion (average: 234111063 ml)(P=0004) The patients of the OA and LA groups began soft diets on the 4811 (37 days) and 2715 postoperative days (18 days), respectively (P=0004) Total frequencies of analgesics were 95±65 and 4447 in the OA and LA groups, respectively (P=0001) The times needed to return to free ambulation were 7638 and 4323 days in the OA and LA groups, respectively (P=0000) Postoperative hospital stays were 16375 and 7323 days in the OA and LA groups, respectively (P=0000) Conclusion: An LA appears to be a safe and effective approach for patients with various adrenal pathologies and large sized adrenal lesions We expect the indications for an LA may be extended to large adrenal tumors as well as primary or metastatic malignant adrenal lesions if the oncologic principles are obeyed (J Korean Surg Soc 2006;70:363-369)

The Comparison of Laparoscopic Adrenalectomy with Open Adrenalectomy

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On Semi-Symmetric Complex Hypersurfaces of a Semi-Definite Complex Space Form

BACKGROUND The present study investigated the prognostic role of adjuvant systemic chemotherapy in patients with node negative, T1c triple negative breast cancer (TNBC) from a nationwide cohort. In addition, the prognostic effect between 3 different chemotherapy regimens were compared in node-negative T1c TNBC patients by subgroup analysis. METHODS From the Korean breast cancer registry database, 1,151 T1c node negative TNBC patients were included in this study. Patients were categorized into four treatment groups according to chemotherapy regimen: (1) no chemotherapy, (2) adriamycin plus cyclophosphamide (AC), (3) adriamycin/epirubicin plus cyclophosphamide plus 5-FU (FAC/FEC), and (4) cyclophosphamide plus 5-FU plus methotrexate (CMF). Overall survival (OS) was evaluated between each patient group. RESULTS Of the 1,151 T1c node negative TNBC patients, 1,006 received adjuvant chemotherapy, while 145 received no chemotherapy. Among the patients receiving adjuvant chemotherapy the distribution of regimens was: 586 AC, 168 FAC/FEC (126 FAC, 42 FEC), and 252 CMF. The mean follow-up time of the full study cohort was 87.98 ± 33.56 months (range = 6-192 months). Patients in the no chemotherapy group showed significantly worse OS compared to each chemotherapy regimen group. However, when OS was compared between each chemotherapy regimen, no significant difference was found. CONCLUSIONS This study showed that adjuvant systemic chemotherapy improved OS in T1c node negative TNBC patients, regardless of chemotherapy between AC, FAC/FEC, and CMF regimens.

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The effect of adjuvant chemotherapy on survival in Korean patients with node negative T1c, triple negative breast cancer.

A complex n-dimensional Kahler manifold of constant holomorphic sectional curvature c is called a complex space form, which is denoted by Mn(c). A complete and simply connected complex space form consists of a complex projective space PnC, a complex Euclidean space Cn or a complex hyperbolic space HnC, according as c>0, c=Q or c<0. In this study of real hypersurfaces of PnC, Takagi [8] classifiedall homogeneous real hypersurfaces and Cecil and Ryan [2] showed also that they are realized as the tubes of constant radius over Kahler submanifolds if the structure vector field$ is principal. And Berndt [1] classifiedall homogeneous real hypersurfaces of HnC and showed that they are realized as the tubes of constant radius over certain submanifolds. According to Takagi's classification theorem and Berndt's one, the principal curvatures and their multiplicitiesof homogeneous real hypersurfaces of Mn(c) are given. Now, let M be a real hypersurface of Mn(c), c^O. Then M has an almost contact metric structure (0, ?, 7],g) induced from the Kahler metric and the almost complex structure of Mn(c). We denote by A the shape operator in the direction of the unit normal on M. Then Okumura [7] and Montiel and Romerc ffilnrnvpri the fnilnwincr

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Young Jin Suh

Papers

The Comparison of Laparoscopic Adrenalectomy with Open Adrenalectomy

On Semi-Symmetric Complex Hypersurfaces of a Semi-Definite Complex Space Form

The effect of adjuvant chemotherapy on survival in Korean patients with node negative T1c, triple negative breast cancer.

Characterizations of real hypersurfaces in complex space forms in terms of curvature tensors

Real hypersurfaces in the complex quadric with Reeb invariant Ricci tensor