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Youtong Wu
Researcher at University of Texas Southwestern Medical Center
Publications - 2
Citations - 667
Youtong Wu is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: BCL10 & Intrinsic apoptosis. The author has an hindex of 2, co-authored 2 publications receiving 497 citations.
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Journal ArticleDOI
Apoptotic Caspases Prevent the Induction of Type I Interferons by Mitochondrial DNA
Anthony Rongvaux,Ruaidhri Jackson,Christian C. D. Harman,Tuo Li,A. Phillip West,Marcel R. de Zoete,Marcel R. de Zoete,Youtong Wu,Brian Yordy,Saquib A. Lakhani,Chia-Yi Kuan,Tadatsugu Taniguchi,Gerald S. Shadel,Zhijian J. Chen,Zhijian J. Chen,Akiko Iwasaki,Akiko Iwasaki,Richard A. Flavell,Richard A. Flavell +18 more
TL;DR: The results show that mitochondria have the capacity to simultaneously expose a cell-intrinsic inducer of the IFN response and to inactivate this response in a caspase-dependent manner, which provides a dual control, which determines whether mitochondria initiate an immunologically silent or a proinflammatory type of cell death.
Journal ArticleDOI
A catalytic-independent role for the LUBAC in NF-κB activation upon antigen receptor engagement and in lymphoma cells
Sonia M. Dubois,Sonia M. Dubois,Catherine Alexia,Catherine Alexia,Youtong Wu,Héloïse M. Leclair,Héloïse M. Leclair,Héloïse M. Leclair,Claire Leveau,Claire Leveau,Emilie Schol,Emilie Schol,Thierry Fest,Karin Tarte,Zhijian J. Chen,Julie Gavard,Julie Gavard,Julie Gavard,Nicolas Bidère,Nicolas Bidère +19 more
TL;DR: A role for the LUBAC is revealed during lymphocyte activation and in B-cell malignancy because it dynamically integrates the CBM and marshals NF-κB optimal activation following antigen receptor ligation independently of its catalytic activity.