Brian Yordy

TL;DR: The results show that mitochondria have the capacity to simultaneously expose a cell-intrinsic inducer of the IFN response and to inactivate this response in a caspase-dependent manner, which provides a dual control, which determines whether mitochondria initiate an immunologically silent or a proinflammatory type of cell death.

TL;DR: Data indicate that autophagy contributes to homeostatic regulation of innate antiviral defense through the clearance of dysfunctional mitochondria, and revealed that ROS associated with mitochondria play a key role in potentiating RLR signaling.

TL;DR: It is shown that dorsal root ganglionic neurons produced little type I IFNs in response to infection with a neurotropic virus, herpes simplex type 1, and that DRG neurons required autophagy to limit HSV-1 replication both in vivo and in vitro.

TL;DR: It is shown that IL-6 cooperates with IL-1β to block the suppressive effect of Tregs on CD4+ T cells, at least in part by controlling their responsiveness to IL-2.

TL;DR: It is demonstrated that IL-1 renders naive CD4(+) T cells refractory to Treg cell-mediated suppression in order to allow their differentiation into Th1 cells.