Yuehong Wu

TL;DR: It is demonstrated that NOD.c3c4 mice congenically derived from the nonobese diabetic strain develop an autoimmune biliary disease (ABD) that models human PBC, and the first ABD (Abd) locus is defined using a congenic mapping approach.

TL;DR: Mice immunized with murine Jo-1 develop a striking combination of muscle and lung inflammation that replicates features of the human anti-synthetase syndrome, and the eventual spreading of B cell epitopes that uniformly occurs 8 weeks post immunization with murines provides additional evidence of an immune response mediated by autoreactive,Jo-1-specific T cells.

TL;DR: The NOD.c3c4 mice developed a novel spontaneous and fatal autoimmune polycystic biliary tract disease, with lymphocytic peribiliary infiltrates and autoantibodies.

TL;DR: A critical role for CD137 acting in the early phase of autoimmune diabetes to enhance regulatory cell production is supported, as disease-associated CD137 alleles are likely ineffectual at stimulating a regulatory T-cell population sufficient to prevent disease.

TL;DR: In this article, the authors showed that co-transfer of B6 Tregs prevented dnTGFβRII CD8 T cell mediated cholangitis in mice.