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Yukihiko Sugita
Researcher at Kyoto University
Publications - 19
Citations - 1228
Yukihiko Sugita is an academic researcher from Kyoto University. The author has contributed to research in topics: RNA & Nucleoprotein. The author has an hindex of 10, co-authored 15 publications receiving 1032 citations. Previous affiliations of Yukihiko Sugita include University of Tokyo & Hokkaido University.
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Journal ArticleDOI
Characterization of H7N9 influenza A viruses isolated from humans
Tokiko Watanabe,Maki Kiso,Satoshi Fukuyama,Noriko Nakajima,Masaki Imai,Shinya Yamada,Shin Murakami,Seiya Yamayoshi,Kiyoko Iwatsuki-Horimoto,Yoshihiro Sakoda,Emi Takashita,Ryan McBride,Takeshi Noda,Masato Hatta,Hirotaka Imai,Dongming Zhao,Noriko Kishida,Masayuki Shirakura,Robert P. de Vries,Shintaro Shichinohe,Masatoshi Okamatsu,Tomokazu Tamura,Yuriko Tomita,Naomi Fujimoto,Kazue Goto,Hiroaki Katsura,Eiryo Kawakami,Izumi Ishikawa,Shinji Watanabe,Mutsumi Ito,Yuko Sakai-Tagawa,Yukihiko Sugita,Ryuta Uraki,Reina Yamaji,Amie J. Eisfeld,Gongxun Zhong,Shufang Fan,Jihui Ping,Eileen A. Maher,Anthony Hanson,Yuko Uchida,Takehiko Saito,Makoto Ozawa,Gabriele Neumann,Hiroshi Kida,Takato Odagiri,James C. Paulson,Hideki Hasegawa,Masato Tashiro,Yoshihiro Kawaoka +49 more
TL;DR: The robust replicative ability in mice, ferrets and nonhuman primates and the limited transmissibility in ferrets of Anhui/1 suggest that A(H7N9) viruses have pandemic potential.
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Influenza Virus-Host Interactome Screen as a Platform for Antiviral Drug Development
Tokiko Watanabe,Eiryo Kawakami,Jason E. Shoemaker,Tiago J. S. Lopes,Yukiko Matsuoka,Yuriko Tomita,Hiroko Kozuka-Hata,Takeo Gorai,Tomoko Kuwahara,Eiji Takeda,Atsushi Nagata,Ryo Takano,Maki Kiso,Makoto Yamashita,Yuko Sakai-Tagawa,Hiroaki Katsura,Naoki Nonaka,Hiroko Fujii,Ken Fujii,Yukihiko Sugita,Takeshi Noda,Hideo Goto,Satoshi Fukuyama,Shinji Watanabe,Gabriele Neumann,Masaaki Oyama,Hiroaki Kitano,Yoshihiro Kawaoka +27 more
TL;DR: A network of virus-host protein interactions based on the stage of the viral life cycle affected upon host factor downregulation is generated and several proteins, notably Golgi-specific brefeldin A-resistant guanine nucleotide exchange factor 1 and JAK1, are validated as potential antiviral drug targets.
Journal ArticleDOI
Structural Basis of Heterochromatin Formation by Human HP1
Shinichi Machida,Yoshimasa Takizawa,Masakazu Ishimaru,Yukihiko Sugita,Satoshi Sekine,Jun-ichi Nakayama,Matthias Wolf,Hitoshi Kurumizaka +7 more
TL;DR: The three-dimensional structure of the H3K9me3-containing dinucleosomes complexed with human HP1α, HP1β, and HP1γ, determined by cryogenic electron microscopy with a Volta phase plate, depicts the fundamental architecture of heterochromatin.
Journal ArticleDOI
Three-dimensional analysis of ribonucleoprotein complexes in influenza A virus.
Takeshi Noda,Yukihiko Sugita,Kazuhiro Aoyama,Kazuhiro Aoyama,Ai Hirase,Eiryo Kawakami,Atsuo Miyazawa,Hiroshi Sagara,Yoshihiro Kawaoka +8 more
TL;DR: This work elucidates, using electron tomography, the three-dimensional structure of ribonucleoprotein complexes (RNPs) within progeny virions, and suggests the existence of a specific mechanism for assembly of these RNPs.
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Cryo-EM structure of the Ebola virus nucleoprotein–RNA complex at 3.6 Å resolution
TL;DR: Near-atomic resolution cryo-electron microscopy structures of the Zaire ebolavirus nucleoprotein indicate a complex transition from the RNA-free to RNA-bound forms of the protein, and reveal the mechanism of oligomer formation and helical assembly.