S
Shin Murakami
Researcher at University of Tokyo
Publications - 59
Citations - 2559
Shin Murakami is an academic researcher from University of Tokyo. The author has contributed to research in topics: Virus & Influenza A virus. The author has an hindex of 18, co-authored 48 publications receiving 2244 citations.
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Journal ArticleDOI
In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses
Yasushi Itoh,Kyoko Shinya,Maki Kiso,Tokiko Watanabe,Yoshihiro Sakoda,Masato Hatta,Yukiko Muramoto,Daisuke Tamura,Yuko Sakai-Tagawa,Takeshi Noda,Saori Sakabe,Masaki Imai,Yasuko Hatta,Shinji Watanabe,Chengjun Li,Shinya Yamada,Ken Fujii,Shin Murakami,Hirotaka Imai,Satoshi Kakugawa,Mutsumi Ito,Ryo Takano,Kiyoko Iwatsuki-Horimoto,Masayuki Shimojima,Taisuke Horimoto,Hideo Goto,Kei Takahashi,Akiko Makino,Hirohito Ishigaki,Misako Nakayama,Masatoshi Okamatsu,Kazuo Takahashi,David Warshauer,Peter A. Shult,Reiko Saito,Hiroshi Suzuki,Yousuke Furuta,Makoto Yamashita,Keiko Mitamura,Kunio Nakano,Morio Nakamura,Rebecca A. Brockman-Schneider,Hiroshi Mitamura,Masahiko Yamazaki,Norio Sugaya,M. Suresh,Makoto Ozawa,Makoto Ozawa,Gabriele Neumann,James E. Gern,Hiroshi Kida,Kazumasa Ogasawara,Yoshihiro Kawaoka +52 more
TL;DR: It is shown that CA04 is sensitive to approved and experimental antiviral drugs, suggesting that these compounds could function as a first line of defence against the recently declared S-OIV pandemic.
Journal ArticleDOI
Characterization of H7N9 influenza A viruses isolated from humans
Tokiko Watanabe,Maki Kiso,Satoshi Fukuyama,Noriko Nakajima,Masaki Imai,Shinya Yamada,Shin Murakami,Seiya Yamayoshi,Kiyoko Iwatsuki-Horimoto,Yoshihiro Sakoda,Emi Takashita,Ryan McBride,Takeshi Noda,Masato Hatta,Hirotaka Imai,Dongming Zhao,Noriko Kishida,Masayuki Shirakura,Robert P. de Vries,Shintaro Shichinohe,Masatoshi Okamatsu,Tomokazu Tamura,Yuriko Tomita,Naomi Fujimoto,Kazue Goto,Hiroaki Katsura,Eiryo Kawakami,Izumi Ishikawa,Shinji Watanabe,Mutsumi Ito,Yuko Sakai-Tagawa,Yukihiko Sugita,Ryuta Uraki,Reina Yamaji,Amie J. Eisfeld,Gongxun Zhong,Shufang Fan,Jihui Ping,Eileen A. Maher,Anthony Hanson,Yuko Uchida,Takehiko Saito,Makoto Ozawa,Gabriele Neumann,Hiroshi Kida,Takato Odagiri,James C. Paulson,Hideki Hasegawa,Masato Tashiro,Yoshihiro Kawaoka +49 more
TL;DR: The robust replicative ability in mice, ferrets and nonhuman primates and the limited transmissibility in ferrets of Anhui/1 suggest that A(H7N9) viruses have pandemic potential.
Journal ArticleDOI
Detection and Characterization of Bat Sarbecovirus Phylogenetically Related to SARS-CoV-2, Japan
Shin Murakami,Tomoya Kitamura,Jin Suzuki,Ryouta Sato,Toshiki Aoi,Marina Fujii,Hiromichi Matsugo,Haruhiko Kamiki,Hiroho Ishida,Akiko Takenaka-Uema,Masayuki Shimojima,Taisuke Horimoto +11 more
TL;DR: The sarbecovirus’ spike protein specifically recognizes angiotensin-converting enzyme 2 of R. cornutus, but not humans, as an entry receptor, which indicates its phylogenetically related to severe acute respiratory syndrome coronavirus 2.
Journal ArticleDOI
Virulence-Affecting Amino Acid Changes in the PA Protein of H7N9 Influenza A Viruses
Seiya Yamayoshi,Shinya Yamada,Satoshi Fukuyama,Shin Murakami,Dongming Zhao,Ryuta Uraki,Tokiko Watanabe,Yuriko Tomita,Catherine A. Macken,Gabriele Neumann,Yoshihiro Kawaoka +10 more
TL;DR: It is found that the PA proteins of A(H7N9) viruses possess several amino acid substitutions that cause attenuation in mammals.
Journal ArticleDOI
The HA and NS genes of human H5N1 influenza A virus contribute to high virulence in ferrets.
Hirotaka Imai,Kyoko Shinya,Ryo Takano,Maki Kiso,Yukiko Muramoto,Saori Sakabe,Shin Murakami,Mutsumi Ito,Shinya Yamada,Mai thi Quynh Le,Chairul A. Nidom,Yuko Sakai-Tagawa,Kei Takahashi,Yasuyuki Omori,Takeshi Noda,Masayuki Shimojima,Satoshi Kakugawa,Hideo Goto,Kiyoko Iwatsuki-Horimoto,Taisuke Horimoto,Yoshihiro Kawaoka +20 more
TL;DR: It is found that the residue at position 134 of HA alters the receptor-binding property of the virus, as measured by viral elution from erythrocytes, and both of the residues at positions 200 and 205 of NS1 contributed to enhanced type I interferon (IFN) antagonistic activity.