Y
Yun Huang
Researcher at Texas A&M University
Publications - 137
Citations - 10404
Yun Huang is an academic researcher from Texas A&M University. The author has contributed to research in topics: DNA methylation & Gene. The author has an hindex of 33, co-authored 124 publications receiving 8762 citations. Previous affiliations of Yun Huang include Texas A&M Health Science Center College of Medicine & Brigham and Women's Hospital.
Papers
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Journal ArticleDOI
A Combination Strategy Targeting Enhancer Plasticity Exerts Synergistic Lethality Against Beti-Resistant Leukemia Cells
Lei Guo,Jia Li,Hongxiang Zeng,Anna Guzman,Tingting Li,Minjung Lee,Yubin Zhou,Clifford Stephan,Peter J.A. Davies,Margaret A. Goodell,Deqiang Sun,Mark A. Dawson,Yun Huang +12 more
TL;DR: It is demonstrated herein that genome-wide enhancer remodeling played a pivotal role in driving therapeutic resistance via compensational re-expression of pro-survival genes and established the feasibility of targeting enhancer plasticity to overcome drug resistance associated with epigenetic therapies.
Posted ContentDOI
Design of smart antibody mimetics with photosensitive switches
TL;DR: A generally-applicable method to engineer light-controllable monobodies and nanobodies, designated as moonbody and sunbody, respectively, that enable rapid and reversible antibody-antigen recognition by utilizing light.
Journal ArticleDOI
Calcium-dependent Association of Calmodulin with the Rubella Virus Nonstructural Protease Domain
Yubin Zhou,Wen-Pin Tzeng,Hing-Cheung Wong,Yiming Ye,Jie Jiang,Yanyi Chen,Yun Huang,Suganthi Suppiah,Teryl K. Frey,Jenny J. Yang +9 more
TL;DR: The Ca2+-dependent, stoichiometric association of calmodulin (CaM) with the RUBV NS protease is reported, and it is demonstrated that association of CaM with the CaM-binding domain in the RubVNS protease was necessary for NS prote enzyme activity and infectivity.
Journal ArticleDOI
Associations of urinary polycyclic aromatic hydrocarbons with age at natural menopause in U.S. women aged 35-65, NHANES 2003-2012.
TL;DR: Positive associations between urinary PAH levels and earlier age at natural menopause in the general U.S. women are suggested and prospects are warranted to confirm the causality in the future.
Book ChapterDOI
The STIM-Orai Pathway: Light-Operated Ca 2+ Entry Through Engineered CRAC Channels.
TL;DR: Most recent advances in engineering CRAC channels to achieve optical control over Ca2+ signaling are reviewed, their design principles and kinetic features are outlined, and exemplary applications of GECAs engineered fromCRAC channels are presented.