Yun Huang

TL;DR: Improved understanding of the effects of environmental stress on emergence of CH with mutation-specific clarity will guide future efforts to provide preventive medicine to individuals with CH.

TL;DR: It is found that unstimulated, SOCE null KO cells still retain 50~70% of ER Ca2+ stores of wildtype (wt) cells, and ER-PM trapping and clustering of STIM molecules only facilitates the process of SOCE activation, but is not essential for the activation of Orai channels.

TL;DR: The present study has demonstrated a Ca2+-dependent, stoichiometric interaction between CaM and a CaM-binding domain (CaMBD) located within the C terminus of CaSR, and suggests a wrapping around 1–14-like mode of interaction that involves global conformational changes in both lobes of CaM with concomitant formation of a helical structure in the CaMBD.

TL;DR: It is found that cardiac-specific deletion of Tet2 and Tet3 in mice (Tet2/3-DKO) leads to ventricular non-compaction cardiomyopathy (NCC) with embryonic lethality, and DNA methylation and hydroxymethylation dynamics during early cardiac development in both human and mice are analyzed.

TL;DR: This work shows human MettL3–MettL14 complex is active in vitro as a DNA adenine-N6 MTase and methylates GGACT in single-strand DNA and double-Strand DNA-containing mismatches.