Y
Yun Huang
Researcher at Texas A&M University
Publications - 137
Citations - 10404
Yun Huang is an academic researcher from Texas A&M University. The author has contributed to research in topics: DNA methylation & Gene. The author has an hindex of 33, co-authored 124 publications receiving 8762 citations. Previous affiliations of Yun Huang include Texas A&M Health Science Center College of Medicine & Brigham and Women's Hospital.
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Journal ArticleDOI
Targeting epigenetic regulatory machinery to overcome cancer therapy resistance
TL;DR: In this article, the potential of combining epigenetic drugs with existing anticancer regimens as a promising strategy for overcoming cancer drug resistance is discussed, where the authors highlight latest discoveries in the mechanistic understanding of epigenetically-induced drug resistance.
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Antibiotic treatment ameliorates Ten-eleven translocation 2 (TET2) loss-of-function associated hematological malignancies.
Hongxiang Zeng,Hailan He,Lei Guo,Jia Li,Minjung Lee,Wei Han,Anna Guzman,Shengbing Zang,Yubin Zhou,Xiaotian Zhang,Margaret A. Goodell,Katherine Y. King,Deqiang Sun,Yun Huang +13 more
TL;DR: The feasibility of targeting pro-inflammatory pathways to curtail TET2 inactivation-associated hematological malignancies is established, and pharmacological inhibition of TNF-α signaling partially attenuated Tet2-deficient tumor cell growth in vivo is found.
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Engineering of a bona fide light-operated calcium channel.
Lian He,Liuqing Wang,Hongxiang Zeng,Peng Tan,Guolin Ma,Sisi Zheng,Yaxin Li,Lin Sun,Fei Dou,Stefan Siwko,Yun Huang,Youjun Wang,Yubin Zhou +12 more
TL;DR: In this article, a light-operated Ca2+-selective ion channel (LOCa) was proposed by inserting a plant-derived photosensory module into the intracellular loop of an engineered ORAI1 channel.
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Molecular determinants for STIM1 activation during store-operated Ca2+ entry.
TL;DR: It is shown that truncation of theSTIM1 luminal domain predisposes STIM1 to adopt a more active conformation, which clarifies the roles of major STIM2 functional domains in maintaining a quiescent configuration of STIM 1 to prevent preactivation of SOCE.
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Bioluminescence probe for γ-glutamyl transpeptidase detection in vivo.
Yuxing Lin,Yuqi Gao,Zhao Ma,Tianyu Jiang,Xin Zhou,Zhenzhen Li,Xiaojun Qin,Yun Huang,Lupei Du,Minyong Li +9 more
TL;DR: To detect γ-Glutamyl Transpeptidase (GGT) activity in vitro and in vivo, a bioluminescence probe with high sensitivity and specificity was well designed and synthesized.