Y
Yun Huang
Researcher at Texas A&M University
Publications - 137
Citations - 10404
Yun Huang is an academic researcher from Texas A&M University. The author has contributed to research in topics: DNA methylation & Gene. The author has an hindex of 33, co-authored 124 publications receiving 8762 citations. Previous affiliations of Yun Huang include Texas A&M Health Science Center College of Medicine & Brigham and Women's Hospital.
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Journal ArticleDOI
Tet2 Inactivation Enhances the Antitumor Activity of Tumor-Infiltrating Lymphocytes.
Minjung Lee,Jianfang Li,Jia Li,Shaohai Fang,Joanna Zhang,Joanna Zhang,Anh Tran Tram Vo,Wei Han,Hongxiang Zeng,Sevinj Isgandarova,Margarita Martinez-Moczygemba,Yubin Zhou,Deqiang Sun,Yun Huang +13 more
TL;DR: In this paper, the authors used a murine model of melanoma to discover that Tet2 inactivation significantly enhances the antitumor activity of TILs with an efficacy comparable to immune checkpoint inhibition imposed by anti-PD-L1 treatment.
Journal ArticleDOI
Associations of fluoride exposure with sex steroid hormones among U.S. children and adolescents, NHANES 2013-2016.
TL;DR: The data indicated gender- and age-specific inverse associations of fluoride in plasma and water with sex steroid hormones of total testosterone, estradiol and SHBG in U.S. children and adolescents.
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Optogenetic Control of Voltage-Gated Calcium Channels.
Guolin Ma,Jindou Liu,Yuepeng Ke,Xin Liu,Minyong Li,Fen Wang,Gang Han,Yun Huang,Youjun Wang,Yubin Zhou +9 more
TL;DR: This optogenetic tool (designated optoRGK) tailored for CaV channels could find broad applications in interrogating a wide range of CaV‐mediated physiological processes.
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Structural basis for preferential binding of human TCF4 to DNA containing 5-carboxylcytosine.
TL;DR: The analyses indicate, and suggest a structural basis for, the preferential recognition of 5caC by a transcription factor centrally important in brain development.
Journal ArticleDOI
Engineered Split-TET2 Enzyme for Inducible Epigenetic Remodeling
Minjung Lee,Jia Li,Yi Liang,Guolin Ma,Jixiang Zhang,Jixiang Zhang,Lian He,Yuliang Liu,Qian Li,Minyong Li,Deqiang Sun,Yubin Zhou,Yun Huang +12 more
TL;DR: A split-TET2 enzyme is engineered to enable temporal control of 5mC oxidation and subsequent remodeling of epigenetic states in mammalian cells, and this chemical-inducible epigenome remodeling tool will find broad use in interrogating cellular systems without altering the genetic code.