Yun Huang

TL;DR: It is demonstrated that SIRT6 functions as a chromatin regulator safeguarding the balance between pluripotency and differentiation through Tet-mediated production of 5hmC.

TL;DR: The first genome-wide mapping of 5-hydroxymethylcytosine in T cells during sequential steps of lineage commitment in the thymus and the periphery is presented, finding that 5hmC is enriched at gene bodies and cell type-specific enhancers, that its levels in the gene body correlate strongly with gene expression and histone modifications, and that its Levels change dynamically during the course of T-cell development and differentiation.

TL;DR: This paper dissects the intact CaSR into three globular subdomains, and predicts more potential noncontinuous Ca(2+)-binding sites in the ECD, to further understand the mechanisms underlying the binding of multiple metal ions to extended polypeptides derived from a location within the E CD of the CaSR.

TL;DR: Current progresses in ATM/ATR research and related signaling pathways are discussed in this review, in an effort to facilitate a better understanding of genotoxic stress response.

TL;DR: It is concluded that DNMT3A and TET1 regulate the epigenome and gene expression at specific targets via their functional interplay and regulate Polycomb Repressive Complex 2-mediated H3K27me3 enrichment to constrain gene expression from bivalent promoters.