Y
Yung-Chi Cheng
Researcher at Yale University
Publications - 834
Citations - 44358
Yung-Chi Cheng is an academic researcher from Yale University. The author has contributed to research in topics: Medicine & Virus. The author has an hindex of 87, co-authored 683 publications receiving 42508 citations. Previous affiliations of Yung-Chi Cheng include University of Georgia & Vion Pharmaceuticals, Inc..
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Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction.
TL;DR: The analysis described shows K I does not equal I 50 when competitive inhibition kinetics apply; however, K I is equal to I 50 under conditions of either noncompetitive or uncompetitive kinetics.
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Transfer of purified herpes virus thymidine kinase gene to cultured mouse cells.
TL;DR: The results prove the usefulness of transfection assays as a means for the bioassay and isolation of restriction fragments carrying specific genetic information and cells expressing HSV-1 tk may also provide a useful model system for the detailed analysis of eucaryotic and viral gene regulation.
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Antisense oligonucleotides as therapeutic agents--is the bullet really magical?
Cy A. Stein,Yung-Chi Cheng +1 more
TL;DR: The potential use of phosphorothioate oligos as inhibitors of viral replication is highlighted and these are examples of oligos that are being considered for clinical therapeutic trials and meet some, but not all, of these criteria.
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A unified model for the flicker noise in metal-oxide-semiconductor field-effect transistors
TL;DR: In this paper, a unified flicker noise model which incorporates both the number fluctuation and the correlated surface mobility fluctuation mechanism is discussed, which can unify the noise data reported in the literature, without making any ad hoc assumption on the noise generation mechanism.
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Inhibition of the replication of hepatitis B virus in vitro by 2',3'-dideoxy-3'-thiacytidine and related analogues.
TL;DR: Two 2',3'-dideoxy-3'-thiapyrimidine nucleosides were found to be the most potent anti-HBV compounds and both SddC and 5-FSddC should be further evaluated for the treatment of human HBV infection.