Yuting Guo

TL;DR: Grazing incidence structured illumination microscopy (GI-SIM) was developed that is capable of imaging dynamic events near the basal cell cortex at 97-nm resolution and 266 frames/s over thousands of time points, and uncovered new ER remodeling mechanisms, such as hitchhiking of the ER on motile organelles.

TL;DR: In this paper, a deep Fourier channel attention network (DFCAN) was proposed to learn hierarchical representations of high-frequency information about diverse biological structures using multimodal structured illumination microscopy (SIM).

TL;DR: In this paper, the contribution of m6A to an individual-long noncoding RNA (MALAT1) was dissected, and it was shown that the concatenated residues on MALAT1 acted as a scaffold for recruiting YTH-domain-containing protein 1 (YTHDC1) to nuclear speckles.

TL;DR: Evidence is provided, using live-cell super-resolution imaging, that nucleoids can be actively transported via KIF5B-driven mitochondrial dynamic tubulation activities that predominantly occur at the ER-mitochondria contact sites (EMCS) and that such active transportation is a mechanism essential for the proper distribution of nucleoids in the peripheral zone of the cell.

TL;DR: An enhanced force measurement technique combining 3D super-resolution fluorescence structural illumination microscopy and traction force microscopy (3D-SIM-TFM) offering increased spatiotemporal resolution is introduced, opening-up unprecedented insights into physiological three-dimensional force production in living cells.