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Yves Engelborghs
Researcher at Katholieke Universiteit Leuven
Publications - 205
Citations - 9695
Yves Engelborghs is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Fluorescence correlation spectroscopy & Integrase. The author has an hindex of 52, co-authored 205 publications receiving 9220 citations. Previous affiliations of Yves Engelborghs include Max Planck Society & Ghent University.
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HIV-1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cells
Peter Cherepanov,Goedele N. Maertens,Paul Proost,Bart Devreese,Jozef Van Beeumen,Yves Engelborghs,Erik De Clercq,Zeger Debyser +7 more
TL;DR: The findings indicate that the minimal IN molecule in human cells is a homotetramer, suggesting that at least an octamer of IN is required to accomplish coordinated integration of both retroviral long terminal repeats and that LEDGF is a cellular factor involved in this process.
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LEDGF/p75 Is Essential for Nuclear and Chromosomal Targeting of HIV-1 Integrase in Human Cells
Goedele N. Maertens,Peter Cherepanov,W Pluymers,Katrien Busschots,Erik De Clercq,Zeger Debyser,Yves Engelborghs +6 more
TL;DR: It is concluded that RNA interference-mediated knock-down of endogenous LEDGF/p75 expression abolished nuclear/chromosomal localization of IN and accounts for the karyophilic properties and chromosomal targeting of HIV-1 IN
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Fluorescence lifetime standards for time and frequency domain fluorescence spectroscopy
Noël Boens,Wenwu Qin,Nikola Basarić,Johan Hofkens,Marcel Ameloot,Jacques Pouget,Jean Pierre Lefèvre,Bernard Valeur,Enrico Gratton,Martin vandeVen,Martin vandeVen,Norberto D. Silva,Yves Engelborghs,K Willaert,Alain Sillen,Garry Rumbles,David Phillips,Antonie J. W. G. Visser,Arie van Hoek,Joseph R. Lakowicz,Henryk Malak,Ignacy Gryczynski,Arthur G. Szabo,Don T. Krajcarski,Naoto Tamai,Atsushi Miura +25 more
TL;DR: A series of fluorophores with single-exponential fluorescence decays in liquid solution at 20 degrees C were measured independently by nine laboratories using single-photon timing and multifrequency phase and modulation fluorometry instruments with lasers as excitation source.
Journal ArticleDOI
The Correct Use of “Average” Fluorescence Parameters
Alain Sillen,Yves Engelborghs +1 more
TL;DR: When more than one fluorophore is present or when one fluorescence displays a multiple exponential decay "average" fluorescence parameters are derived, which can be combined with ''average'' lifetimes for further interpretation as mentioned in this paper.
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The Endocrine Disruptor Monoethyl-hexyl-phthalate Is a Selective Peroxisome Proliferator-activated Receptor γ Modulator That Promotes Adipogenesis
Jerome N. Feige,Laurent Gelman,Daniel Rossi,Vincent Zoete,Raphaël Métivier,Cicerone Tudor,Silvia I. Anghel,Aurélien Grosdidier,Caroline Lathion,Yves Engelborghs,Olivier Michielin,Walter Wahli,Béatrice Desvergne +12 more
TL;DR: Structural and functional analyses are performed that demonstrate how monoethyl-hexyl-phthalate (MEHP) directly activates PPARγ and promotes adipogenesis, albeit to a lower extent than the full agonist rosiglitazone.