Z
Zhaohui Gu
Researcher at City of Hope National Medical Center
Publications - 3
Citations - 108
Zhaohui Gu is an academic researcher from City of Hope National Medical Center. The author has contributed to research in topics: Enhancer & Stem cell marker. The author has an hindex of 2, co-authored 3 publications receiving 15 citations. Previous affiliations of Zhaohui Gu include National University of Singapore & Beckman Research Institute.
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Journal ArticleDOI
Enhancer Hijacking Drives Oncogenic BCL11B Expression in Lineage-Ambiguous Stem Cell Leukemia.
Lindsey E. Montefiori,Sonja Bendig,Zhaohui Gu,Xiao-Long Chen,Petri Pölönen,Xiaotu Ma,Alex Murison,Andy G.X. Zeng,Laura García-Prat,Kirsten Dickerson,Ilaria Iacobucci,Sherif Abdelhamed,Ryan Hiltenbrand,Paul E. Mead,Cyrus M. Mehr,Beisi Xu,Zhongshan Cheng,Ti-Cheng Chang,Tamara Westover,Jing Ma,Anna Stengel,Shunsuke Kimura,Chunxu Qu,Marcus B. Valentine,Marissa Rashkovan,Selina M. Luger,Mark R. Litzow,Jacob M. Rowe,Monique L. den Boer,Victoria Wang,Jun Yin,Steven M. Kornblau,Stephen P. Hunger,Mignon L. Loh,Ching-Hon Pui,Wenjian Yang,Kristine R. Crews,Kathryn G. Roberts,Jun J. Yang,Mary V. Relling,William E. Evans,Wendy Stock,Elisabeth Paietta,Adolfo A. Ferrando,Jinghui Zhang,Wolfgang Kern,Torsten Haferlach,Gang Wu,John E. Dick,Jeffery M. Klco,Claudia Haferlach,Charles G. Mullighan +51 more
TL;DR: In this paper, the authors describe a distinct subgroup of acute leukemia with expression of myeloid, T lymphoid, and stem cell markers driven by aberrant allele-specific deregulation of BCL11B, a master transcription factor responsible for thymic T-lineage commitment and specification.
Journal ArticleDOI
Clinical significance of novel subtypes of acute lymphoblastic leukemia in the context of minimal residual disease-directed therapy.
Sima Jeha,John Choi,Roberts Kathryn,Deqing Pei,Elaine Coustan-Smith,Hiroto Inaba,Jeffrey E. Rubnitz,Raul C. Ribeiro,Tanja A. Gruber,Susana C. Raimondi,Seth E. Karol,Chunxu Qu,Samuel W. Brady,Zhaohui Gu,Jun J. Yang,Cheng Cheng,James R. Downing,Williams E. Evans,Mary V. Relling,Dario Campana,Charles G. Mullighan,Ching-Hon Pui +21 more
TL;DR: New subtypes of acute lymphoblastic leukemia have important prognostic and therapeutic implications, including DUX4-rearranged, PAX5alt, BCR-ABL1-like, ETV6-RUNX1- like, MEF2D-re arranged and ZNF384- rearranged ALL.
Journal ArticleDOI
Enhancer Hijacking of BCL11B Defines a Subtype of Lineage Ambiguous Acute Leukemia
Lindsey E. Montefiori,Sonja Seliger,Zhaohui Gu,Xiaotu Ma,Beisi Xu,Xiao-Long Chen,Kirsten Dickerson,Tamara Westover,Anna Stengel,Ilaria Iacobucci,Shunsuke Kimura,Chunxu Qu,Jing Ma,Marc Valentine,Wolfgang Kern,Torsten Haferlach,Gang Wu,Jeffery M. Klco,Claudia Haferlach,Charles G. Mullighan +19 more
TL;DR: A large pan-acute leukemia analysis of 2,573 samples revealed a new subtype of 60 samples with a distinct gene expression profile and immunophenotype that exhibited monoallelic expression of BCL11B which encodes a T-lineage transcription factor that is repressed in hematopoietic stem and progenitor cells (HSPCs), a putative cell of origin for ALAL.