M
Marc Valentine
Researcher at St. Jude Children's Research Hospital
Publications - 18
Citations - 1199
Marc Valentine is an academic researcher from St. Jude Children's Research Hospital. The author has contributed to research in topics: Philadelphia chromosome & Heterochromatin. The author has an hindex of 12, co-authored 18 publications receiving 900 citations.
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Journal ArticleDOI
Long-term safety and efficacy following systemic administration of a self-complementary AAV vector encoding human FIX pseudotyped with serotype 5 and 8 capsid proteins.
Amit C. Nathwani,Amit C. Nathwani,Cecilia Rosales,Jenny McIntosh,Ghasem Rastegarlari,Devhrut Nathwani,Deepak Raj,Sushmita Nawathe,Simon N. Waddington,Roderick T. Bronson,Scott Jackson,Robert E. Donahue,Katherine A. High,Federico Mingozzi,Catherine Y.C. Ng,Junfang Zhou,Yunyu Spence,M. Beth McCarville,Marc Valentine,James A. Allay,John Coleman,Susan Sleep,John T. Gray,Arthur W. Nienhuis,Andrew M. Davidoff +24 more
TL;DR: The long-term consequences of a single intravenous administration of a self-complementary AAV vector encoding a codon optimized human factor IX gene in 24 nonhuman primates revealed no toxicity, and data support further evaluation of this vector in hemophilia B patients.
Journal ArticleDOI
Targetable kinase gene fusions in high-risk B-ALL: a study from the Children's Oncology Group.
Shalini C. Reshmi,Shalini C. Reshmi,Richard C. Harvey,Kathryn G. Roberts,Eileen Stonerock,Amy Smith,Heather Jenkins,I-Ming Chen,Marc Valentine,Yu Liu,Yongjin Li,Ying Shao,John Easton,Debbie Payne-Turner,Zhaohui Gu,Thai Hoa Tran,Jonathan V. Nguyen,Meenakshi Devidas,Yunfeng Dai,Nyla A. Heerema,Andrew J. Carroll,Elizabeth A. Raetz,Michael J. Borowitz,Brent L. Wood,Anne L. Angiolillo,Michael J. Burke,Wanda L. Salzer,Patrick A. Zweidler-McKay,Karen R. Rabin,William L. Carroll,Jinghui Zhang,Mignon L. Loh,Charles G. Mullighan,Cheryl L. Willman,Julie M. Gastier-Foster,Julie M. Gastier-Foster,Stephen P. Hunger +36 more
TL;DR: The current findings provide support for the precision-medicine testing and treatment approach for Ph-like ALL implemented in Children's Oncology Group ALL trials.
Journal ArticleDOI
The Dynamic Epigenetic Landscape of the Retina During Development, Reprogramming, and Tumorigenesis.
Issam Aldiri,Beisi Xu,Lu Wang,Xiang Chen,Daniel J. Hiler,Lyra Griffiths,Marc Valentine,Abbas Shirinifard,Suresh Thiagarajan,Andras Sablauer,Marie E. Barabas,Jiakun Zhang,Dianna A. Johnson,Sharon Frase,Xin Zhou,John Easton,Jinghui Zhang,Elaine R. Mardis,Richard K. Wilson,James R. Downing,Michael A. Dyer,Michael A. Dyer,Michael A. Dyer +22 more
TL;DR: In the developing retina, multipotent neural progenitors undergo unidirectional differentiation in a precise spatiotemporal order as mentioned in this paper, and the most dramatic change was derepression of cell-type-specific differentiation programs.
Journal ArticleDOI
Genomic and outcome analyses of Ph-like ALL in NCI standard-risk patients: a report from the Children's Oncology Group.
Kathryn G. Roberts,Shalini C. Reshmi,Shalini C. Reshmi,Richard C. Harvey,I-Ming Chen,Kinnari Patel,Eileen Stonerock,Heather Jenkins,Yunfeng Dai,Marc Valentine,Zhaohui Gu,Yaqi Zhao,Jinghui Zhang,Debbie Payne-Turner,Meenakshi Devidas,Nyla A. Heerema,Andrew J. Carroll,Elizabeth A. Raetz,Michael J. Borowitz,Brent L. Wood,Leonard A. Mattano,Kelly W. Maloney,William L. Carroll,Mignon L. Loh,Cheryl L. Willman,Julie M. Gastier-Foster,Julie M. Gastier-Foster,Charles G. Mullighan,Stephen P. Hunger +28 more
TL;DR: It is established that genomic alterations potentially targetable with approved kinase inhibitors are less frequent in SR than in HR ALL and clinical outcome of Ph-like ALL is improved.
Journal ArticleDOI
Nucleome Dynamics during Retinal Development.
Jackie L. Norrie,Marybeth S. Lupo,Beisi Xu,Issam Al Diri,Marc Valentine,Daniel Putnam,Lyra Griffiths,Jiakun Zhang,Dianna A. Johnson,John Easton,Ying Shao,Victoria Honnell,Sharon Frase,Shondra Miller,Valerie Stewart,Xin Zhou,Xiang Chen,Michael A. Dyer,Michael A. Dyer,Michael A. Dyer +19 more
TL;DR: A machine learning-based algorithm was developed to map euchromatin and heterochromatin domains genome-wide and overlaid it with chromatin compartments identified by Hi-C, which identified developmental-stage-specific changes in chromatincompartments and enhancer-promoter interactions.