Z
Zhaojie Zhang
Researcher at St. Jude Children's Research Hospital
Publications - 17
Citations - 1367
Zhaojie Zhang is an academic researcher from St. Jude Children's Research Hospital. The author has contributed to research in topics: Medicine & Cancer. The author has an hindex of 8, co-authored 12 publications receiving 1048 citations. Previous affiliations of Zhaojie Zhang include University of Colorado Boulder.
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Journal ArticleDOI
Genomic Landscape of Ewing Sarcoma Defines an Aggressive Subtype with Co-Association of STAG2 and TP53 Mutations
Franck Tirode,Didier Surdez,Xiaotu Ma,Matthew Parker,Marie-Cécile Le Deley,Armita Bahrami,Zhaojie Zhang,Eve Lapouble,Sandrine Grossetête-Lalami,Michael Rusch,Stéphanie Reynaud,Thomas Rio-Frio,Erin Hedlund,Gang Wu,Xiang Chen,Gaëlle Pierron,Odile Oberlin,Sakina Zaidi,Gordon Lemmon,Pankaj Gupta,Bhavin Vadodaria,John Easton,Marta Gut,Li Ding,Elaine R. Mardis,Richard K. Wilson,Sheila A. Shurtleff,Valérie Laurence,Jean Michon,Perrine Marec-Berard,Ivo Gut,James R. Downing,Michael A. Dyer,Michael A. Dyer,Jinghui Zhang,Olivier Delattre +35 more
TL;DR: Tumors that harbor STAG2 and TP53 mutations have a particularly dismal prognosis with current treatments and require alternative therapies, and novel drugs that target epigenetic regulators may constitute viable therapeutic strategies in a subset of patients with mutations in chromatin modifiers.
Journal ArticleDOI
Exploring genomic alteration in pediatric cancer using ProteinPaint.
Xin Zhou,Michael N. Edmonson,Mark R. Wilkinson,Aman Patel,Gang Wu,Yu Liu,Yongjin Li,Zhaojie Zhang,Michael Rusch,Matthew Parker,Jared Becksfort,James R. Downing,Jinghui Zhang +12 more
TL;DR: This paper presents a meta-analyses of the prophylactic and experimental studies conducted at the BGI-Shenzhen and South China University of Technology of Beijing Genomics Institute of Bioengineering and showed clear trends in prognosis and prognosis for women with high-risk pregnancies.
Journal ArticleDOI
Quantitative functions of Argonaute proteins in mammalian development
Dongmei Wang,Zhaojie Zhang,Evan O’Loughlin,Thomas Lee,Thomas Lee,Stephane Houel,Stephane Houel,Dónal O'Carroll,Alexander Tarakhovsky,Natalie G. Ahn,Natalie G. Ahn,Rui Yi +11 more
TL;DR: It is reported that microRNAs are randomly sorted to individual Argonautes in mammals, independent of the slicer activity, and the results reveal a quantitative picture for microRNA activity in mammals.
Journal ArticleDOI
Clinical cancer genomic profiling by three-platform sequencing of whole genome, whole exome and transcriptome
Michael Rusch,Joy Nakitandwe,Sheila A. Shurtleff,Scott Newman,Zhaojie Zhang,Michael N. Edmonson,Matthew Parker,Yuannian Jiao,Xiaotu Ma,Yanling Liu,Jiali Gu,Michael Walsh,Jared Becksfort,Andrew Thrasher,Yongjin Li,James McMurry,Erin Hedlund,Aman Patel,John Easton,Donald Yergeau,Bhavin Vadodaria,Ruth G. Tatevossian,Susana C. Raimondi,Dale Hedges,Xiang Chen,Kohei Hagiwara,Rose B. McGee,Giles W. Robinson,Jeffery M. Klco,Tanja A. Gruber,David W. Ellison,James R. Downing,Jinghui Zhang +32 more
TL;DR: A three-platform approach (whole-genome, whole-exome, and whole-transcriptome) in pediatric patients for the detection of diverse types of germline and somatic variants in pediatric oncology testing is presented.
Journal ArticleDOI
MicroRNA-205 controls neonatal expansion of skin stem cells by modulating the PI(3)K pathway
Dongmei Wang,Zhaojie Zhang,Evan O’Loughlin,Evan O’Loughlin,Li Wang,Xiying Fan,Eric C. Lai,Rui Yi +7 more
TL;DR: It is reported that an essential role for miR-205, one of the most highly expressed microRNAs in skin SCs, in promoting neonatal expansion of these cells by antagonizing negative regulators of PI(3)K signalling.