Zhe Sha

TL;DR: This elegant mechanism allows cells to compensate for reduced proteasome function by enhancing production of 26S subunits and p97, which performs limited proteolysis that generates the active form of Nrf1.

TL;DR: It is shown that mammalian 26S proteasomes have five associated ubiquitin ligases and that multiple proteasome subunits are ubiquitinated in cells, especially the ubiquit in receptor subunit, Rpn13, which strongly decreases the prote asome's ability to bind and degrade ubiqu itin‐conjugated proteins, but not its activity against peptide substrates.

TL;DR: The data reveal the breadth of the eIF3 interactome and suggest that factors involved in translation initiation, ribosome biogenesis, translation elongation, quality control, and transport are physically linked to facilitate efficient protein synthesis.

TL;DR: It is shown that clinically achievable inhibition of the β5 site of the proteasome by Cfz and Btz does not result in loss of viability of triple-negative breast cancer cell lines, providing a strong rationale for the development of dual β5 and β2 inhibitors for the treatment of solid tumors.

TL;DR: Proteasome inhibitors are used as research tools and to treat multiple myeloma, and proteasome activity is diminished in several neurodegenerative diseases, so this study studied how cells compensate for proteasomesome inhibition.