Zhen Zhang

TL;DR: This review analyzes the cancer gene‐delivery cascade and the barriers, the needed nanopro properties and the current strategies for overcoming these barriers, and outlines PEGylation, surface‐charge, size, and stability dilemmas in vector nanoproperties to efficiently accomplish the cancer genes delivery cascade.

TL;DR: In this paper, the authors showed that conjugates of small-molecule anticancer drugs with poly(2-(Noxide-N, N-diethylamino)ethyl methacrylate) have long blood-circulation half-lives and bind reversibly to cell membranes, owing to the negligible interaction of the polyzwitterion with proteins and its weak interaction with phospholipids.

TL;DR: A novel platform for parallel synthesis of low cationic charge-density polyesters for efficient gene delivery and G-1 polyplexes efficiently delivered the suicide gene pTRAIL to intraperitoneal tumors and elicited effective anticancer activity.

TL;DR: A potent paraptosis-inducing nanomedicine is reported that causes quick nonapoptotic death of cancer cells, overcoming apoptosis-based resistance and effectively inhibiting drug-resistant tumor growth.

TL;DR: An efficient synthesis of enzyme-responsive phosphoramidate (PAD) dendrimers from a pair of monomers using click and click-like reactions is reported, which showed improved therapeutic effects and reduced toxicity in athymic nude mice bearing xenografts of MCF-7/ADR breast cancer.