Zhen Zhang

TL;DR: An haemagglutinin stem-directed bnAb, 3I14, isolated from human memory B cells, that utilizes a heavy chain encoded by the IGHV3-30 germline gene is reported, providing evidence that memory B cell evolution can expand the HA subtype specificity.

TL;DR: G6 binding studies demonstrate the remarkable breadth of binding to 51p1 IGHV1-69 Abs with diverse CDR-H3, light chain, and antigen binding specificities and detail the broad expression of the G6 cross-reactive idiotype that further define its potential role in precision medicine.

TL;DR: In this paper , a lineage of naturally occurring human antibodies sharing the same germline gene, VH3-48/VK1-12, were reported to broadly neutralize the major circulating strains of IAV in vitro and in vivo mainly by binding a contiguous epitope of H3N2 HA, but a conformational epitope within H1N1 HA, respectively.

TL;DR: Results demonstrate that the novel bsAb format is feasible and effective, suggesting great potential as an inspiring antiviral strategy, and shows potent prophylactic and therapeutic efficacy against SARS-CoV-2 in three established mouse models.