Z
Zheng Huang
Researcher at Merck & Co.
Publications - 50
Citations - 2509
Zheng Huang is an academic researcher from Merck & Co.. The author has contributed to research in topics: Stearoyl-CoA Desaturase & Phospholipase A2. The author has an hindex of 26, co-authored 50 publications receiving 2419 citations. Previous affiliations of Zheng Huang include United States Military Academy.
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Journal ArticleDOI
Slow- and tight-binding inhibitors of the 85-kDa human phospholipase A2.
Ian P. Street,Hung-Kuei Lin,F. Laliberte,Farideh Ghomashchi,Zhaoyin Wang,Helene Perrier,Nathalie Tremblay,Zheng Huang,Philip K. Weech,Michael H. Gelb +9 more
TL;DR: A trifluoromethyl ketone analogue of arachidonic acid in which the COOH group is replaced with COCF3 was prepared and found to be a tight- and slow-binding inhibitor of the 85-kDa cytosolic human phospholipase A2 (cPLA2).
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Deletion of phosphodiesterase 4D in mice shortens α2-adrenoceptor–mediated anesthesia, a behavioral correlate of emesis
Annette Robichaud,Panagiota B. Stamatiou,S.-L. Catherine Jin,Nicholas Lachance,Dwight Macdonald,Susana Liu,Zheng Huang,Marco Conti,Chi-Chung Chan +8 more
TL;DR: Findings strongly support the hypothesis that inhibition of PDE4D is pivotal to the anesthesia-reversing effect of PMNPQ and is likely responsible for emesis induced by PDE 4 inhibitors.
Journal ArticleDOI
The next generation of PDE4 inhibitors.
TL;DR: A number of highly potent PDE4 inhibitors are being developed for the treatment of asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, multiple sclerosis and Crohn's disease.
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Development of a liver-targeted stearoyl-CoA desaturase (SCD) inhibitor (MK-8245) to establish a therapeutic window for the treatment of diabetes and dyslipidemia.
Renata Oballa,Liette Belair,W. Cameron Black,Kelly Bleasby,Chi-Chung Chan,Carole Desroches,Xiaobing Du,R. Gordon,Jocelyne Guay,Sébastien Guiral,Michael J. Hafey,Emelie Hamelin,Zheng Huang,Brian P. Kennedy,Nicolas Lachance,Chun Sing Li,Joseph A. Mancini,Denis Normandin,Alessandro Pocai,David A. Powell,Yeeman K. Ramtohul,Kathryn Skorey,Dan Sørensen,Wayne Sturkenboom,Angela Styhler,Deena Waddleton,Hao Wang,Simon Wong,Lijing Xu,Lei Zhang +29 more
TL;DR: The discovery of MK-8245 is found, a potent, liver-targeted SCD inhibitor with preclinical antidiabetic and antidyslipidemic efficacy with a significantly improved therapeutic window.
Journal ArticleDOI
Functional identification of the active-site nucleophile of the human 85-kDa cytosolic phospholipase A2
TL;DR: Evidence is presented to show that the hydroxyl group of Ser-228 is the catalytic nucleophile of cPLA2 and that cysteine can replace serine as the nucleophile, resulting in a thiol-cPLA2 with significantly reduced catalytic power.